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10.3389/fimmu.2020.01070 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.01070 32582174!7287163!32582174     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 1070 Nephropedia Template TP {{tp|p=32582174|t=2020. Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis |pdf=|usr=}}{{32582174}} gab.com Text Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32582174 #FOAvip Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing three monocyte subsets in humans. These phenotypic subsets, termed classical, intermediate and nonclassical, have also been demonstrated to differ in regard to their functional properties and disease associations when studied in vitro and in vivo. Nonetheless, for the intermediate monocyte subset in particular, functional experiments have yielded conflicting results and some studies point to further levels of heterogeneity. Developments in genetic sequencing technology have provided opportunities to more comprehensively explore the phenotypic and functional differences among conventionally-recognized immune cell subtypes as well as the potential to identify novel subpopulations. In this review, we summarize the transcriptomic evidence in support of the existence of three separate monocyte subsets. We also critically evaluate the insights into subset functional distinctions that have been garnered from monocyte gene expression analysis and the potential utility of such studies to unravel subset-specific functional changes which arise in disease states. Twit Text FOAVip Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32582174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32582174 #FOAvip English Wikipedia <ref>{{Cite pmid|32582174}}</ref> Human Monocyte Subset Distinctions and Function: Insights From Gene Expression Analysis #MMPMID32582174 Cormican S; Griffin MD Front Immunol 2020[]; 11 (ä): 1070 PMID32582174show ga Monocytes are a highly plastic innate immune cell population that displays significant heterogeneity within the circulation. Distinct patterns of surface marker expression have become accepted as a basis for distinguishing three monocyte subsets in humans. These phenotypic subsets, termed classical, intermediate and nonclassical, have also been demonstrated to differ in regard to their functional properties and disease associations when studied in vitro and in vivo. Nonetheless, for the intermediate monocyte subset in particular, functional experiments have yielded conflicting results and some studies point to further levels of heterogeneity. Developments in genetic sequencing technology have provided opportunities to more comprehensively explore the phenotypic and functional differences among conventionally-recognized immune cell subtypes as well as the potential to identify novel subpopulations. In this review, we summarize the transcriptomic evidence in support of the existence of three separate monocyte subsets. We also critically evaluate the insights into subset functional distinctions that have been garnered from monocyte gene expression analysis and the potential utility of such studies to unravel subset-specific functional changes which arise in disease states. |GPI-Linked Proteins/metabolism[MESH] |Gene Expression Profiling/*methods/trends[MESH] |Humans[MESH] |Immune System Diseases/etiology/genetics/immunology[MESH] |Immunity, Innate/genetics[MESH] |Immunophenotyping[MESH] |Lipopolysaccharide Receptors/metabolism[MESH] |Monocytes/*classification/*immunology/metabolism[MESH]Human Monocyte Subset Distinctions and Function: Insights From Gene Ex(epmc).pdf DeepDyve Pubget Overpricing