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10.5582/ddt.2020.03046 http://scihub22266oqcxt.onion/10.5582/ddt.2020.03046 32581194!ä!32581194 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Discov+Ther 2020 ; 14 (3): 143-144 Nephropedia Template TP {{tp|p=32581194|t=2020. Targeting lymphocyte Kv1 3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy?|pdf=|usr=}}{{32581194}} gab.com Text Targeting lymphocyte Kv1 3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy JO: Drug Discov Ther http://www.kidney.de/pget.php?&tw=1&pmid=32581194 #FOAvip In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In "chronic inflammatory diseases", the overexpression of delayed rectifier K(+)-channels (Kv1.3) in leukocytes is responsible for the overactivation of cellular immunity and the subsequent cytokine storm. In our previous basic studies, drugs including chloroquine and azithromycin strongly suppressed the channel activity and pro-inflammatory cytokine production from lymphocytes. These findings suggest a novel pharmacological mechanism by which chloroquine, with or without azithromycin, is effective for severe cases of COVID-19, in which the overactivation of cellular immunity and the subsequent cytokine storm are responsible for the pathogenesis. Twit Text FOAVip Targeting lymphocyte Kv1 3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy ????Drug Discov Ther http://www.kidney.de/pget.php?&tw=1&pmid=32581194 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32581194 #FOAvip English Wikipedia <ref>{{Cite pmid|32581194}}</ref> Targeting lymphocyte Kv1 3-channels to suppress cytokine storm in severe COVID-19: Can it be a novel therapeutic strategy? #MMPMID32581194 Kazama I Drug Discov Ther 2020[Jul]; 14 (3): 143-144 PMID32581194show ga In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In "chronic inflammatory diseases", the overexpression of delayed rectifier K(+)-channels (Kv1.3) in leukocytes is responsible for the overactivation of cellular immunity and the subsequent cytokine storm. In our previous basic studies, drugs including chloroquine and azithromycin strongly suppressed the channel activity and pro-inflammatory cytokine production from lymphocytes. These findings suggest a novel pharmacological mechanism by which chloroquine, with or without azithromycin, is effective for severe cases of COVID-19, in which the overactivation of cellular immunity and the subsequent cytokine storm are responsible for the pathogenesis. |*Betacoronavirus[MESH] |Azithromycin/administration & dosage[MESH] |COVID-19[MESH] |Chloroquine/administration & dosage[MESH] |Coronavirus Infections/*drug therapy/metabolism[MESH] |Cytokines/*antagonists & inhibitors/metabolism[MESH] |Drug Delivery Systems/*methods/trends[MESH] |Humans[MESH] |Kv1.3 Potassium Channel/*antagonists & inhibitors/metabolism[MESH] |Lymphocytes/*drug effects/metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/metabolism[MESH] |SARS-CoV-2[MESH]Targeting lymphocyte Kv1 3-channels to suppress cytokine storm in seve(epmc).pdf DeepDyve Pubget Overpricing