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10.1016/j.addr.2020.06.013 http://scihub22266oqcxt.onion/10.1016/j.addr.2020.06.013 32579890!7306214!32579890     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Drug+Deliv+Rev 2020 ; 157 (ä): 96-117 Nephropedia Template TP {{tp|p=32579890|t=2020. Targeting drug delivery in the vascular system: Focus on endothelium |pdf=|usr=}}{{32579890}} gab.com Text Targeting drug delivery in the vascular system: Focus on endothelium JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=32579890 #FOAvip The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the site of administration to the intended site of action. In many cases, components of the vascular system represent therapeutic targets. Endothelial cells, which line the luminal surface of the vasculature, play a tripartite role of the key target, barrier, or victim of nanomedicines in the bloodstream. Circulating DDS may accumulate in the vascular areas of interest and in off-target areas via mechanisms bypassing specific molecular recognition, but using ligands of specific vascular determinant molecules enables a degree of precision, efficacy, and specificity of delivery unattainable by non-affinity DDS. Three decades of research efforts have focused on specific vascular targeting, which have yielded a multitude of DDS, many of which are currently undergoing a translational phase of development for biomedical applications, including interventions in the cardiovascular, pulmonary, and central nervous systems, regulation of endothelial functions, host defense, and permeation of vascular barriers. We discuss the design of endothelial-targeted nanocarriers, factors underlying their interactions with cells and tissues, and describe examples of their investigational use in models of acute vascular inflammation with an eye on translational challenges. Twit Text FOAVip Targeting drug delivery in the vascular system: Focus on endothelium ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=32579890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32579890 #FOAvip English Wikipedia <ref>{{Cite pmid|32579890}}</ref> Targeting drug delivery in the vascular system: Focus on endothelium #MMPMID32579890 Glassman PM; Myerson JW; Ferguson LT; Kiseleva RY; Shuvaev VV; Brenner JS; Muzykantov VR Adv Drug Deliv Rev 2020[]; 157 (ä): 96-117 PMID32579890show ga The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the site of administration to the intended site of action. In many cases, components of the vascular system represent therapeutic targets. Endothelial cells, which line the luminal surface of the vasculature, play a tripartite role of the key target, barrier, or victim of nanomedicines in the bloodstream. Circulating DDS may accumulate in the vascular areas of interest and in off-target areas via mechanisms bypassing specific molecular recognition, but using ligands of specific vascular determinant molecules enables a degree of precision, efficacy, and specificity of delivery unattainable by non-affinity DDS. Three decades of research efforts have focused on specific vascular targeting, which have yielded a multitude of DDS, many of which are currently undergoing a translational phase of development for biomedical applications, including interventions in the cardiovascular, pulmonary, and central nervous systems, regulation of endothelial functions, host defense, and permeation of vascular barriers. We discuss the design of endothelial-targeted nanocarriers, factors underlying their interactions with cells and tissues, and describe examples of their investigational use in models of acute vascular inflammation with an eye on translational challenges. |*Drug Delivery Systems[MESH] |Animals[MESH] |Endothelial Cells/metabolism[MESH] |Endothelium, Vascular/cytology/*metabolism[MESH] |Humans[MESH] |Inflammation/drug therapy[MESH] |Nanomedicine[MESH] |Nanoparticles[MESH]Targeting drug delivery in the vascular system: Focus on endothelium (epmc).pdf DeepDyve Pubget Overpricing