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10.1002/jcph.1697 http://scihub22266oqcxt.onion/10.1002/jcph.1697 32579707!7361784!32579707     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Pharmacol 2020 ; 60 (9): 1147-1154 Nephropedia Template TP {{tp|p=32579707|t=2020. Clinical Pharmacology Considerations for Developing Small-Molecule Treatments for COVID-19 |pdf=|usr=}}{{32579707}} gab.com Text Clinical Pharmacology Considerations for Developing Small-Molecule Treatments for COVID-19 JO: J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32579707 #FOAvip Numerous drugs are being investigated for the treatment of COVID-19, including antivirals and therapies targeting complications related to COVID-19. The clinical presentation of COVID-19 varies from mild fever, cough, and dyspnea in the early stages of disease to severe complications such as acute respiratory distress syndrome, systemic hyperinflammation, and sepsis. A thorough understanding of the disease pathogenesis and the disease complications is essential to developing effective therapies to treat this potentially life-threatening disease. This review offers key clinical pharmacology considerations involved in the development of small molecules for the treatment of COVID-19. They are based on the major observed disease complications that impact drug absorption, distribution, metabolism, and elimination. We also address considerations regarding potential drug interactions, alternative routes and methods of administration, and dosing in patients on hemodialysis. Twit Text FOAVip Clinical Pharmacology Considerations for Developing Small-Molecule Treatments for COVID-19 ????J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32579707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32579707 #FOAvip English Wikipedia <ref>{{Cite pmid|32579707}}</ref> Clinical Pharmacology Considerations for Developing Small-Molecule Treatments for COVID-19 #MMPMID32579707 Brunsdon P; Saluja B; Sahajwalla C J Clin Pharmacol 2020[Sep]; 60 (9): 1147-1154 PMID32579707show ga Numerous drugs are being investigated for the treatment of COVID-19, including antivirals and therapies targeting complications related to COVID-19. The clinical presentation of COVID-19 varies from mild fever, cough, and dyspnea in the early stages of disease to severe complications such as acute respiratory distress syndrome, systemic hyperinflammation, and sepsis. A thorough understanding of the disease pathogenesis and the disease complications is essential to developing effective therapies to treat this potentially life-threatening disease. This review offers key clinical pharmacology considerations involved in the development of small molecules for the treatment of COVID-19. They are based on the major observed disease complications that impact drug absorption, distribution, metabolism, and elimination. We also address considerations regarding potential drug interactions, alternative routes and methods of administration, and dosing in patients on hemodialysis. |*COVID-19 Drug Treatment[MESH] |*Drug Development[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |COVID-19/complications/virology[MESH] |Drug Interactions[MESH]Clinical Pharmacology Considerations for Developing Small-Molecule Tre(epmc).pdf DeepDyve Pubget Overpricing