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10.1002/ppul.24921

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32579293!7361845!32579293
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suck abstract from ncbi


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pmid32579293      Pediatr+Pulmonol 2020 ; 55 (9): 2419-2426
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  • Clinical characteristics of acute respiratory syndrome with SARS-CoV-2 infection in children in South China #MMPMID32579293
  • Zheng G; Wang B; Zhang H; Xie C; Zhang Y; Wen Z; Guo Q; Zhu H; Ye G; Liang J; Meng Q; Xie J; Jiang S; Liu G; Gao W; Wang Y; Guo Y
  • Pediatr Pulmonol 2020[Sep]; 55 (9): 2419-2426 PMID32579293show ga
  • BACKGROUND: A retrospective study was conducted to summarize the clinical information of childhood infections during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic. METHODS: Children with SARS-CoV-2 infection in 11 hospitals from three provinces of South China were included in the study. Clinical information was collected and compared with children and adults infected by SARS-CoV-2 in Wuhan. RESULTS: In total, 52 children were enrolled, including 28 boys. The median age was 9 years (interquartile range [IQR], 4-12); 44.2% cases were of clustered occurrences, 40.4% patients had fever, 48.1% had cough, and 46.2% had a high lymphocyte count. No abnormalities were found in the liver and kidney function. Also, 82.7% of patients received antiviral therapy, but such therapy did not shorten the time to virus negativity or hospital stay (P = .082). The time to virus negativity was 12.0 days (IQR, 8.0-16.8) and hospital stay was 14.5 days (IQR, 10.3-17.9). Compared with reports in Wuhan, there were more acute upper respiratory tract infection (AURTI) and fewer pneumonia cases (P = .000). Compared with the non-ICU adult COVID-19 in Wuhan, these children's diseases were relatively mild, with fewer complications. CONCLUSIONS: Children with SARS-CoV-2 infection had a mild fever, lymphocyte elevation was more common than reduction, and antiviral treatment had no obvious effect. The overall clinical manifestations were mild, and the prognosis was good.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/diagnosis/epidemiology/immunology[MESH]
  • |*SARS-CoV-2[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19 Testing[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |China/epidemiology[MESH]
  • |Cough/diagnosis/drug therapy/epidemiology/immunology[MESH]
  • |Epidemics[MESH]
  • |Female[MESH]
  • |Fever/diagnosis/drug therapy/epidemiology/immunology[MESH]
  • |Humans[MESH]
  • |Infant[MESH]
  • |Infant, Newborn[MESH]
  • |Length of Stay[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]


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