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Antiviral activities of mycophenolic acid and IMD-0354 against SARS-CoV-2 #MMPMID32579258
Kato F; Matsuyama S; Kawase M; Hishiki T; Katoh H; Takeda M
Microbiol Immunol 2020[Sep]; 64 (9): 635-639 PMID32579258show ga
In this study, the anti-severe acute respiratory syndrome coronavirus-2 (anti-SARS-CoV-2) activity of mycophenolic acid (MPA) and IMD-0354 was analyzed. These compounds were chosen based on their antiviral activities against other coronaviruses. Because they also inhibit dengue virus (DENV) infection, other anti-DENV compounds/drugs were also assessed. On SARS-CoV-2-infected VeroE6/TMPRSS2 monolayers, both MPA and IMD-0354, but not other anti-DENV compounds/drugs, showed significant anti-SARS-CoV-2 activity. Although MPA reduced the viral RNA level by only approximately 100-fold, its half maximal effective concentration was as low as 0.87 micro m, which is easily achievable at therapeutic doses of mycophenolate mofetil. MPA targets the coronaviral papain-like protease and an in-depth study on its mechanism of action would be useful in the development of novel anti-SARS-CoV-2 drugs.
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Microbiol+Immunol 2020 ; 64 (9): 635-639
