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10.1016/j.xcrm.2020.100015 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100015 32577626!7311075!32577626     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2020 ; 1 (2): ä Nephropedia Template TP {{tp|p=32577626|t=2020. Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans |pdf=|usr=}}{{32577626}} gab.com Text Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32577626 #FOAvip Induction of persistent HIV-1 Envelope (Env) specific antibody (Ab) is a primary goal of HIV vaccine strategies; however, it is unclear whether HIV Env immunization in humans induces bone marrow plasma cells, the presumed source of long-lived systemic Ab. To define the features of Env-specific plasma cells after vaccination, samples were obtained from HVTN 105, a phase I trial testing the same gp120 protein immunogen, AIDSVAX B/E, used in RV144, along with a DNA immunogen in various prime and boost strategies. Boosting regimens that included AIDSVAX B/E induced robust peripheral blood plasmablast responses. The Env-specific immunoglobulin repertoire of the plasmablasts is dominated by VH1 gene usage and targeting of the V3 region. Numerous plasmablast-derived immunoglobulin lineages persisted in the bone marrow >8 months after immunization, including in the CD138(+) long-lived plasma cell compartment. These findings identify a cellular linkage for the development of sustained Env-specific Abs following vaccination in humans. Twit Text FOAVip Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32577626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32577626 #FOAvip English Wikipedia <ref>{{Cite pmid|32577626}}</ref> Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells after Vaccination in Humans #MMPMID32577626 Basu M; Piepenbrink MS; Francois C; Roche F; Zheng B; Spencer DA; Hessell AJ; Fucile CF; Rosenberg AF; Bunce CA; Liesveld J; Keefer MC; Kobie JJ Cell Rep Med 2020[May]; 1 (2): ä PMID32577626show ga Induction of persistent HIV-1 Envelope (Env) specific antibody (Ab) is a primary goal of HIV vaccine strategies; however, it is unclear whether HIV Env immunization in humans induces bone marrow plasma cells, the presumed source of long-lived systemic Ab. To define the features of Env-specific plasma cells after vaccination, samples were obtained from HVTN 105, a phase I trial testing the same gp120 protein immunogen, AIDSVAX B/E, used in RV144, along with a DNA immunogen in various prime and boost strategies. Boosting regimens that included AIDSVAX B/E induced robust peripheral blood plasmablast responses. The Env-specific immunoglobulin repertoire of the plasmablasts is dominated by VH1 gene usage and targeting of the V3 region. Numerous plasmablast-derived immunoglobulin lineages persisted in the bone marrow >8 months after immunization, including in the CD138(+) long-lived plasma cell compartment. These findings identify a cellular linkage for the development of sustained Env-specific Abs following vaccination in humans. |AIDS Vaccines/*therapeutic use[MESH] |Antibody Specificity[MESH] |Cell Lineage/immunology[MESH] |Cell Survival/immunology[MESH] |Cells, Cultured[MESH] |HEK293 Cells[MESH] |HIV Infections/pathology/*prevention & control/virology[MESH] |HIV-1/immunology/physiology[MESH] |Humans[MESH] |Plasma Cells/*immunology/metabolism/pathology/virology[MESH] |THP-1 Cells[MESH] |Vaccination[MESH]Persistence of HIV-1 Env-Specific Plasmablast Lineages in Plasma Cells(epmc).pdf DeepDyve Pubget Overpricing