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10.5455/medarh.2020.74.134-138 http://scihub22266oqcxt.onion/10.5455/medarh.2020.74.134-138 32577056!7296400!32577056     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32577056.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Med+Arch 2020 ; 74 (2): 134-138 Nephropedia Template TP {{tp|p=32577056|t=2020. The Nrf2 Activator (DMF) and Covid-19: Is there a Possible Role?|pdf=|usr=}}{{32577056}} gab.com Text The Nrf2 Activator (DMF) and Covid-19: Is there a Possible Role JO: Med Arch http://www.kidney.de/pget.php?&tw=1&pmid=32577056 #FOAvip INTRODUCTION: COVID-19 is a new viral illness that can affect the lungs and airways with lethal consequences leading to the death of the patients. The ACE2 receptors were widely disturbed among body tissues such as lung, kidney, small intestine, heart, and others in different percent and considered a target for the nCOVID-19 virus. S-protein of the virus was binding to ACE2 receptors caused downregulation of endogenous anti-viral mediators, upregulation of NF-kappaB pathway, ROS and pro-apoptotic protein. Nrf2 was a transcription factor that's play a role in generation of anti-oxidant enzymes. AIM: To describe and establish role of Nrf2 activators for treatment COVID-19 positive patients. METHODS: We used method of analysis of the published papers with described studies about COVID-19 connected with pharmacological issues and aspects which are included in global fighting against COVID-19 infection, and how using DMF (Nrf2 activator) in clinical trial for nCOVID-19 produce positive effects in patients for reduce lung alveolar cells damage. RESULTS: we are found that Nrf2 activators an important medication that's have a role in reduce viral pathogenesis via inhibit virus entry through induce SPLI gene expression as well as inhibit TRMPSS2, upregulation of ACE2 that's make a competition with the virus on binding site, induce gene expression of anti-viral mediators such as RIG-1 and INFs, induce anti-oxidant enzymes, also they have a role in inhibit NF-kappaB pathway, inhibit both apoptosis proteins and gene expression of TLRs. CONCLUSION: We are concluded that use DMF (Nrf2 activator) in clinical trial for nCOVID-19 positive patients to reduce lung alveolar cells damage. Twit Text FOAVip The Nrf2 Activator (DMF) and Covid-19: Is there a Possible Role ????Med Arch http://www.kidney.de/pget.php?&tw=1&pmid=32577056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32577056 #FOAvip English Wikipedia <ref>{{Cite pmid|32577056}}</ref> The Nrf2 Activator (DMF) and Covid-19: Is there a Possible Role? #MMPMID32577056 Hassan SM; Jawad MJ; Ahjel SW; Singh RB; Singh J; Awad SM; Hadi NR Med Arch 2020[Apr]; 74 (2): 134-138 PMID32577056show ga INTRODUCTION: COVID-19 is a new viral illness that can affect the lungs and airways with lethal consequences leading to the death of the patients. The ACE2 receptors were widely disturbed among body tissues such as lung, kidney, small intestine, heart, and others in different percent and considered a target for the nCOVID-19 virus. S-protein of the virus was binding to ACE2 receptors caused downregulation of endogenous anti-viral mediators, upregulation of NF-kappaB pathway, ROS and pro-apoptotic protein. Nrf2 was a transcription factor that's play a role in generation of anti-oxidant enzymes. AIM: To describe and establish role of Nrf2 activators for treatment COVID-19 positive patients. METHODS: We used method of analysis of the published papers with described studies about COVID-19 connected with pharmacological issues and aspects which are included in global fighting against COVID-19 infection, and how using DMF (Nrf2 activator) in clinical trial for nCOVID-19 produce positive effects in patients for reduce lung alveolar cells damage. RESULTS: we are found that Nrf2 activators an important medication that's have a role in reduce viral pathogenesis via inhibit virus entry through induce SPLI gene expression as well as inhibit TRMPSS2, upregulation of ACE2 that's make a competition with the virus on binding site, induce gene expression of anti-viral mediators such as RIG-1 and INFs, induce anti-oxidant enzymes, also they have a role in inhibit NF-kappaB pathway, inhibit both apoptosis proteins and gene expression of TLRs. CONCLUSION: We are concluded that use DMF (Nrf2 activator) in clinical trial for nCOVID-19 positive patients to reduce lung alveolar cells damage. |Alveolar Epithelial Cells/metabolism[MESH] |Betacoronavirus/*metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/*metabolism[MESH] |Humans[MESH] |Lung/*metabolism[MESH] |NF-E2-Related Factor 2/*metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*metabolism[MESH] |Pulmonary Alveoli/metabolism[MESH]The Nrf2 Activator (DMF) and Covid-19: Is there a Possible Role?(epmc).pdf DeepDyve Pubget Overpricing