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10.1038/s41577-020-0357-7

http://scihub22266oqcxt.onion/10.1038/s41577-020-0357-7
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32576980!7309428!32576980
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suck abstract from ncbi


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pmid32576980      Nat+Rev+Immunol 2020 ; 20 (8): 507-514
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  • GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches #MMPMID32576980
  • Lang FM; Lee KM; Teijaro JR; Becher B; Hamilton JA
  • Nat Rev Immunol 2020[Aug]; 20 (8): 507-514 PMID32576980show ga
  • Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific merits behind these contrasting approaches.
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |Granulocyte-Macrophage Colony-Stimulating Factor/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]


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