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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Rev+Immunol 2020 ; 20 (8): 507-514 Nephropedia Template TP
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GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches #MMPMID32576980
Lang FM; Lee KM; Teijaro JR; Becher B; Hamilton JA
Nat Rev Immunol 2020[Aug]; 20 (8): 507-514 PMID32576980show ga
Therapeutics against coronavirus disease 2019 (COVID-19) are urgently needed. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a myelopoietic growth factor and pro-inflammatory cytokine, plays a critical role in alveolar macrophage homeostasis, lung inflammation and immunological disease. Both administration and inhibition of GM-CSF are currently being therapeutically tested in COVID-19 clinical trials. This Perspective discusses the pleiotropic biology of GM-CSF and the scientific merits behind these contrasting approaches.