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10.1016/j.tips.2020.06.001 http://scihub22266oqcxt.onion/10.1016/j.tips.2020.06.001 32576386!7305739!32576386     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Pharmacol+Sci 2020 ; 41 (8): 518-530 Nephropedia Template TP {{tp|p=32576386|t=2020. Deciphering the TCR Repertoire to Solve the COVID-19 Mystery |pdf=|usr=}}{{32576386}} gab.com Text Deciphering the TCR Repertoire to Solve the COVID-19 Mystery JO: Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32576386 #FOAvip The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date. Important questions have remained unanswered: why some patients develop severe disease, while others do not; and what roles do genetic variabilities play in the individual immune response to this viral infection. Here, we discuss the critical role T cells play in the orchestration of the antiviral response underlying the pathogenesis of the disease, COVID-19. We highlight the scientific rationale for comprehensive and longitudinal TCR analyses in COVID-19 and reason that analyzing TCR repertoire in COVID-19 patients would reveal important findings that may explain the outcome disparity observed in these patients. Finally, we provide a framework describing the different strategies, the advantages, and the challenges involved in obtaining useful TCR repertoire data to advance our fight against COVID-19. Twit Text FOAVip Deciphering the TCR Repertoire to Solve the COVID-19 Mystery ????Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32576386 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32576386 #FOAvip English Wikipedia <ref>{{Cite pmid|32576386}}</ref> Deciphering the TCR Repertoire to Solve the COVID-19 Mystery #MMPMID32576386 Gutierrez L; Beckford J; Alachkar H Trends Pharmacol Sci 2020[Aug]; 41 (8): 518-530 PMID32576386show ga The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected several millions and killed more than quarter of a million worldwide to date. Important questions have remained unanswered: why some patients develop severe disease, while others do not; and what roles do genetic variabilities play in the individual immune response to this viral infection. Here, we discuss the critical role T cells play in the orchestration of the antiviral response underlying the pathogenesis of the disease, COVID-19. We highlight the scientific rationale for comprehensive and longitudinal TCR analyses in COVID-19 and reason that analyzing TCR repertoire in COVID-19 patients would reveal important findings that may explain the outcome disparity observed in these patients. Finally, we provide a framework describing the different strategies, the advantages, and the challenges involved in obtaining useful TCR repertoire data to advance our fight against COVID-19. |Animals[MESH] |Betacoronavirus/*isolation & purification[MESH] |COVID-19[MESH] |Coronavirus Infections/*epidemiology/genetics/immunology[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*epidemiology/genetics/immunology[MESH] |Receptors, Antigen, T-Cell/*immunology[MESH] |SARS-CoV-2[MESH]Deciphering the TCR Repertoire to Solve the COVID-19 Mystery (epmc).pdf DeepDyve Pubget Overpricing