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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Liver+Int 2020 ; 40 (9): 2160-2163 Nephropedia Template TP
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Metabolic-associated fatty liver disease is associated with severity of COVID-19 #MMPMID32573883
Zhou YJ; Zheng KI; Wang XB; Sun QF; Pan KH; Wang TY; Ma HL; Chen YP; George J; Zheng MH
Liver Int 2020[Sep]; 40 (9): 2160-2163 PMID32573883show ga
The Corona Virus Disease 2019 (COVID-19) pandemic has attracted increasing worldwide attention. While metabolic-associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVID-19 severity has not been characterized. We identified 55 MAFLD patients with COVID-19, who were 1:1 matched by age, sex and obesity status to non-aged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients without MAFLD. Our results demonstrate that in patients aged less than 60 years with COVID-19, MAFLD is associated with an approximately fourfold increase (adjusted odds ratio 4.07, 95% confidence interval 1.20-13.79, P = .02) in the probability for severe disease, after adjusting for confounders. Healthcare professionals caring for patients with COVID-19 need to be aware that there is a positive association between MAFLD and severe illness with COVID-19.