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10.7554/eLife.57877

http://scihub22266oqcxt.onion/10.7554/eLife.57877
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32573433!7311167!32573433
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suck abstract from ncbi


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pmid32573433      Elife 2020 ; 9 (ä): ä
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  • Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization #MMPMID32573433
  • Klasse PJ; Moore JP
  • Elife 2020[Jun]; 9 (ä): ä PMID32573433show ga
  • We review aspects of the antibody response to SARS-CoV-2, the causative agent of the COVID-19 pandemic. The topics we cover are relevant to immunotherapy with plasma from recovered patients, monoclonal antibodies against the viral S-protein, and soluble forms of the receptor for the virus, angiotensin converting enzyme 2. The development of vaccines against SARS-CoV-2, an essential public health tool, will also be informed by an understanding of the antibody response in infected patients. Although virus-neutralizing antibodies are likely to protect, antibodies could potentially trigger immunopathogenic events in SARS-CoV-2-infected patients or enhance infection. An awareness of these possibilities may benefit clinicians and the developers of antibody-based therapies and vaccines.
  • |*Immunization, Passive[MESH]
  • |Antibodies, Monoclonal[MESH]
  • |Antibodies, Viral[MESH]
  • |Betacoronavirus/immunology[MESH]
  • |Broadly Neutralizing Antibodies/immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Coronavirus Infections/*immunology/*therapy[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology/*therapy[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/immunology[MESH]


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