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10.1073/pnas.2009799117 http://scihub22266oqcxt.onion/10.1073/pnas.2009799117 32571934!7368255!32571934     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2020 ; 117 (28): 16587-16595 Nephropedia Template TP {{tp|p=32571934|t=2020. Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development |pdf=|usr=}}{{32571934}} gab.com Text Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32571934 #FOAvip At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2-infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2-infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naive hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs. Twit Text FOAVip Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=32571934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32571934 #FOAvip English Wikipedia <ref>{{Cite pmid|32571934}}</ref> Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development #MMPMID32571934 Imai M; Iwatsuki-Horimoto K; Hatta M; Loeber S; Halfmann PJ; Nakajima N; Watanabe T; Ujie M; Takahashi K; Ito M; Yamada S; Fan S; Chiba S; Kuroda M; Guan L; Takada K; Armbrust T; Balogh A; Furusawa Y; Okuda M; Ueki H; Yasuhara A; Sakai-Tagawa Y; Lopes TJS; Kiso M; Yamayoshi S; Kinoshita N; Ohmagari N; Hattori SI; Takeda M; Mitsuya H; Krammer F; Suzuki T; Kawaoka Y Proc Natl Acad Sci U S A 2020[Jul]; 117 (28): 16587-16595 PMID32571934show ga At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2-infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and regions of lung consolidation. SARS-CoV-2-infected hamsters mounted neutralizing antibody responses and were protected against subsequent rechallenge with SARS-CoV-2. Moreover, passive transfer of convalescent serum to naive hamsters efficiently suppressed the replication of the virus in the lungs even when the serum was administrated 2 d postinfection of the serum-treated hamsters. Collectively, these findings demonstrate that this Syrian hamster model will be useful for understanding SARS-CoV-2 pathogenesis and testing vaccines and antiviral drugs. |*Disease Models, Animal[MESH] |Animals[MESH] |Antibodies, Neutralizing/blood[MESH] |Antibodies, Viral/blood[MESH] |Betacoronavirus/pathogenicity/physiology[MESH] |COVID-19[MESH] |COVID-19 Serotherapy[MESH] |Cell Line[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/pathology/therapy/*virology[MESH] |Cricetinae[MESH] |Humans[MESH] |Immunization, Passive[MESH] |Lung/diagnostic imaging/*pathology/virology[MESH] |Mesocricetus[MESH] |Pandemics[MESH] |Pneumonia, Viral/pathology/*virology[MESH] |Ribonucleoproteins/chemistry[MESH] |SARS-CoV-2[MESH] |Vero Cells[MESH] |Viral Proteins/chemistry[MESH]Syrian hamsters as a small animal model for SARS-CoV-2 infection and (epmc).pdf DeepDyve Pubget Overpricing