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10.1126/science.abc6952 http://scihub22266oqcxt.onion/10.1126/science.abc6952 32571838!7319273!32571838     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 369 (6504): 650-655 Nephropedia Template TP {{tp|p=32571838|t=2020. A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 |pdf=|usr=}}{{32571838}} gab.com Text A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32571838 #FOAvip Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein but also across the full Spike (S) protein. We isolated and characterized monoclonal antibodies (mAbs) from 10 convalescent COVID-19 patients. Three mAbs showed neutralizing activities against authentic SARS-CoV-2. One mAb, named 4A8, exhibits high neutralization potency against both authentic and pseudotyped SARS-CoV-2 but does not bind the RBD. We defined the epitope of 4A8 as the N-terminal domain (NTD) of the S protein by determining with cryo-eletron microscopy its structure in complex with the S protein to an overall resolution of 3.1 angstroms and local resolution of 3.3 angstroms for the 4A8-NTD interface. This points to the NTD as a promising target for therapeutic mAbs against COVID-19. Twit Text FOAVip A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32571838 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32571838 #FOAvip English Wikipedia <ref>{{Cite pmid|32571838}}</ref> A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2 #MMPMID32571838 Chi X; Yan R; Zhang J; Zhang G; Zhang Y; Hao M; Zhang Z; Fan P; Dong Y; Yang Y; Chen Z; Guo Y; Zhang J; Li Y; Song X; Chen Y; Xia L; Fu L; Hou L; Xu J; Yu C; Li J; Zhou Q; Chen W Science 2020[Aug]; 369 (6504): 650-655 PMID32571838show ga Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be guided by the distribution of epitopes, not only on the receptor binding domain (RBD) of the Spike (S) protein but also across the full Spike (S) protein. We isolated and characterized monoclonal antibodies (mAbs) from 10 convalescent COVID-19 patients. Three mAbs showed neutralizing activities against authentic SARS-CoV-2. One mAb, named 4A8, exhibits high neutralization potency against both authentic and pseudotyped SARS-CoV-2 but does not bind the RBD. We defined the epitope of 4A8 as the N-terminal domain (NTD) of the S protein by determining with cryo-eletron microscopy its structure in complex with the S protein to an overall resolution of 3.1 angstroms and local resolution of 3.3 angstroms for the 4A8-NTD interface. This points to the NTD as a promising target for therapeutic mAbs against COVID-19. |Adult[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Monoclonal/blood/chemistry/*immunology/metabolism[MESH] |Antibodies, Neutralizing/blood/chemistry/*immunology/metabolism[MESH] |Antibodies, Viral/blood/chemistry/*immunology/metabolism[MESH] |Antibody Affinity[MESH] |Antibody Specificity[MESH] |Antigens, Viral/immunology[MESH] |B-Lymphocytes/immunology[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*immunology/therapy[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Cryoelectron Microscopy[MESH] |Enzyme-Linked Immunosorbent Assay[MESH] |Genes, Immunoglobulin Heavy Chain[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Middle Aged[MESH] |Mutation[MESH] |Nucleocapsid Proteins/immunology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Phosphoproteins[MESH] |Pneumonia, Viral/*immunology/therapy[MESH] |Protein Domains[MESH] |Protein Interaction Domains and Motifs/immunology[MESH] |Receptors, Coronavirus[MESH] |Receptors, Virus/metabolism[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/*immunology/metabolism[MESH] |Vero Cells[MESH]A neutralizing human antibody binds to the N-terminal domain of the Sp(epmc).pdf DeepDyve Pubget Overpricing