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10.1134/S0006297920050016 http://scihub22266oqcxt.onion/10.1134/S0006297920050016 32571182!7232917!32571182     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32571182&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochemistry+(Mosc) 2020 ; 85 (5): 523-530 Nephropedia Template TP {{tp|p=32571182|t=2020. Molecular Targets in the Chemotherapy of Coronavirus Infection |pdf=|usr=}}{{32571182}} gab.com Text Molecular Targets in the Chemotherapy of Coronavirus Infection JO: Biochemistry (Mosc) http://www.kidney.de/pget.php?&tw=1&pmid=32571182 #FOAvip In the pathogenesis of the infectious process in the respiratory tract by SARS, MERS, and COVID-19 coronaviruses, two stages can be distinguished: early (etiotropic) and late (pathogenetic) ones. In the first stage, when the virus multiplication and accumulation are prevalent under insufficient host immune response, the use of chemotherapeutic agents blocking the reproduction of the virus is reasonable to suppress the development of the disease. This article considers six major chemotherapeutic classes aimed at certain viral targets: inhibitors of viral RNA polymerase, inhibitors of viral protease Mpro, inhibitors of proteolytic activation of viral protein S allowing virus entry into the target cell, inhibitors of virus uncoating in cellular endosomes, compounds of exogenous interferons, and compounds of natural and recombinant virus-neutralizing antibodies. In the second stage, when the multiplication of the virus decreases and threatening pathological processes of excessive inflammation, acute respiratory distress syndrome, pulmonary edema, hypoxia, and secondary bacterial pneumonia and sepsis events develop, a pathogenetic therapeutic approach including extracorporeal blood oxygenation, detoxification, and anti-inflammatory and anti-bacterial therapy seems to be the most effective way for the patient's recovery. Twit Text FOAVip Molecular Targets in the Chemotherapy of Coronavirus Infection ????Biochemistry (Mosc) http://www.kidney.de/pget.php?&tw=1&pmid=32571182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32571182 #FOAvip English Wikipedia <ref>{{Cite pmid|32571182}}</ref> Molecular Targets in the Chemotherapy of Coronavirus Infection #MMPMID32571182 Zhirnov OP Biochemistry (Mosc) 2020[May]; 85 (5): 523-530 PMID32571182show ga In the pathogenesis of the infectious process in the respiratory tract by SARS, MERS, and COVID-19 coronaviruses, two stages can be distinguished: early (etiotropic) and late (pathogenetic) ones. In the first stage, when the virus multiplication and accumulation are prevalent under insufficient host immune response, the use of chemotherapeutic agents blocking the reproduction of the virus is reasonable to suppress the development of the disease. This article considers six major chemotherapeutic classes aimed at certain viral targets: inhibitors of viral RNA polymerase, inhibitors of viral protease Mpro, inhibitors of proteolytic activation of viral protein S allowing virus entry into the target cell, inhibitors of virus uncoating in cellular endosomes, compounds of exogenous interferons, and compounds of natural and recombinant virus-neutralizing antibodies. In the second stage, when the multiplication of the virus decreases and threatening pathological processes of excessive inflammation, acute respiratory distress syndrome, pulmonary edema, hypoxia, and secondary bacterial pneumonia and sepsis events develop, a pathogenetic therapeutic approach including extracorporeal blood oxygenation, detoxification, and anti-inflammatory and anti-bacterial therapy seems to be the most effective way for the patient's recovery. |Antibodies, Viral/therapeutic use[MESH] |Antiviral Agents/pharmacology[MESH] |Betacoronavirus/*drug effects/enzymology/immunology[MESH] |COVID-19[MESH] |Coronavirus 3C Proteases[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Cysteine Endopeptidases[MESH] |DNA-Directed RNA Polymerases/antagonists & inhibitors[MESH] |Drug Therapy, Combination[MESH] |Humans[MESH] |Interferon alpha-2/therapeutic use[MESH] |Molecular Targeted Therapy/*methods[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/antagonists & inhibitors[MESH] |Viral Nonstructural Proteins/antagonists & inhibitors[MESH] |Virus Internalization/drug effects[MESH]Molecular Targets in the Chemotherapy of Coronavirus Infection (epmc).pdf DeepDyve Pubget Overpricing