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10.1016/j.mehy.2020.109999

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109999
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32570168!7294251!32570168
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suck abstract from ncbi


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pmid32570168      Med+Hypotheses 2020 ; 144 (ä): 109999
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  • Microvascular disease confers additional risk to COVID-19 infection #MMPMID32570168
  • Bale BF; Doneen AL; Vigerust DJ
  • Med Hypotheses 2020[Nov]; 144 (ä): 109999 PMID32570168show ga
  • The majority of fatalities thus far in the COVID-19 pandemic have been attributed to pneumonia. As expected, the fatality rate reported in China is higher in people with chronic pulmonary disease (6.3%) and those who have cancer (5.6%). According to the American College of Cardiology Clinical Bulletin "COVID-19 Clinical Guidance for the CV Care Team", there is a significantly higher fatality rate in people who are elderly (8.0% 70-79 years; 14.8% >/=80 years), diabetic (7.3%), hypertensive (6.0%), or have known cardiovascular disease (CVD) (10.5%). We propose a biological reason for the higher mortality risk in these populations that is apparent. We further present a set of pathophysiological reasons for the heightened danger that could lead to therapies for enhanced management and prevention.
  • |*Immunity, Innate[MESH]
  • |*Pandemics[MESH]
  • |Adult[MESH]
  • |Aging/immunology[MESH]
  • |COVID-19/*epidemiology/etiology/immunology[MESH]
  • |Cardiovascular Diseases/epidemiology/immunology[MESH]
  • |Child[MESH]
  • |Diabetes Mellitus/epidemiology/immunology[MESH]
  • |Disease Susceptibility[MESH]
  • |Humans[MESH]
  • |Hydrogen Peroxide/metabolism[MESH]
  • |Hypertension/epidemiology/immunology[MESH]
  • |Hypochlorous Acid/metabolism[MESH]
  • |Lung/blood supply/immunology[MESH]
  • |Microcirculation[MESH]
  • |Microvessels/physiopathology[MESH]
  • |Neutrophils/immunology/metabolism[MESH]
  • |Peroxidase/metabolism[MESH]
  • |Risk Factors[MESH]


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