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10.1016/j.virusres.2020.198070

http://scihub22266oqcxt.onion/10.1016/j.virusres.2020.198070
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32569708!7305708!32569708
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suck abstract from ncbi


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pmid32569708      Virus+Res 2020 ; 286 (ä): 198070
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  • COVID-19: Review on latest available drugs and therapies against SARS-CoV-2 Coagulation and inflammation cross-talking #MMPMID32569708
  • Magro G
  • Virus Res 2020[Sep]; 286 (ä): 198070 PMID32569708show ga
  • SARS-CoV-2 is the agent responsible for COVID-19. The infection can be dived into three phases: mild infection, the pulmonary phase and the inflammatory phase. Treatment options for the pulmonary phase include: Hydroxychloroquine, Remdesivir, Lopinavir/Ritonavir. The inflammatory phase includes therapeutic options like Tocilizumab, Anakinra, Baricitinib, Eculizumab, Emapalumab and Heparin. Human clinical trials are starting to show some results, in some cases like that of Remdesivir and corticosteroids these are controversial. Coagulopathy is a common complication in severe cases, inflammation and coagulation are intertwined and cross-talking between these two responses is known to happen. A possible amplification of this cross-talking is suggested to be implicated in the severe cases that show both a cytokine storm and coagulopathy.
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Anti-Inflammatory Agents/*therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antibodies, Monoclonal/therapeutic use[MESH]
  • |Antibodies, Neutralizing/therapeutic use[MESH]
  • |Anticoagulants/*therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Azetidines/therapeutic use[MESH]
  • |Betacoronavirus/*drug effects/immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/virology[MESH]
  • |Cytokine Release Syndrome/*drug therapy/virology[MESH]
  • |Disseminated Intravascular Coagulation/*drug therapy/virology[MESH]
  • |Drug Combinations[MESH]
  • |Heparin/therapeutic use[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/therapeutic use[MESH]
  • |Inflammation[MESH]
  • |Interleukin 1 Receptor Antagonist Protein/therapeutic use[MESH]
  • |Lopinavir/therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/virology[MESH]
  • |Purines[MESH]
  • |Pyrazoles[MESH]
  • |Ritonavir/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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