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10.1097/MCA.0000000000000914 http://scihub22266oqcxt.onion/10.1097/MCA.0000000000000914 32568741!7365584!32568741     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32568741&cmd=llinks): Failed to open stream: HTTP request failed! 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Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease |pdf=|usr=}}{{32568741}} gab.com Text Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease JO: Coron Artery Dis http://www.kidney.de/pget.php?&tw=1&pmid=32568741 #FOAvip OBJECTIVE: COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in patients with COVID-19. METHODS: For this multi-center retrospective study, data of consecutive patients who were treated for COVID-19 between 20 March and 20 April 2020 were collected. Clinical characteristics, laboratory findings and outcomes data were obtained from electronic medical records. In-hospital clinical outcome was compared between patients with and without cardiac injury. RESULTS: A total of 607 hospitalized patients with COVID-19 were included in the study; the median age was 62.5 +/- 14.3 years, and 334 (55%) were male. Cardiac injury was detected in 150 (24.7%) of patients included in the study. Mortality rate was higher in patients with cardiac injury (42% vs. 8%; P < 0.01). The frequency of patients who required ICU (72% vs. 19%), who developed acute kidney injury (14% vs. 1%) and acute respiratory distress syndrome (71%vs. 18%) were also higher in patients with cardiac injury. In multivariate analysis, age, coronary artery disease (CAD), elevated CRP levels, and presence of cardiac injury [odds ratio (OR) 10.58, 95% confidence interval (CI) 2.42-46.27; P < 0.001) were found to be independent predictors of mortality. In subgroup analysis, including patients free of history of CAD, presence of cardiac injury on admission also predicted mortality (OR 2.52, 95% CI 1.17-5.45; P = 0.018). CONCLUSION: Cardiac injury on admission is associated with worse clinical outcome and higher mortality risk in COVID-19 patients including patients free of previous CAD diagnosis. Twit Text FOAVip Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease ????Coron Artery Dis http://www.kidney.de/pget.php?&tw=1&pmid=32568741 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32568741 #FOAvip English Wikipedia <ref>{{Cite pmid|32568741}}</ref> Prognostic significance of cardiac injury in COVID-19 patients with and without coronary artery disease #MMPMID32568741 Barman HA; Atici A; Sahin I; Alici G; Aktas Tekin E; Baycan OF; Ozturk F; Oflar E; Tugrul S; Yavuz MB; Celik FB; Oktay A; Vahaboglu H; Adas M; Turgut N; Okuyan E; Yildirmak MT; Gungor B Coron Artery Dis 2021[Aug]; 32 (5): 359-366 PMID32568741show ga OBJECTIVE: COVID-19 is a disease with high mortality, and risk factors for worse clinical outcome have not been well-defined yet. The aim of this study is to delineate the prognostic importance of presence of concomitant cardiac injury on admission in patients with COVID-19. METHODS: For this multi-center retrospective study, data of consecutive patients who were treated for COVID-19 between 20 March and 20 April 2020 were collected. Clinical characteristics, laboratory findings and outcomes data were obtained from electronic medical records. In-hospital clinical outcome was compared between patients with and without cardiac injury. RESULTS: A total of 607 hospitalized patients with COVID-19 were included in the study; the median age was 62.5 +/- 14.3 years, and 334 (55%) were male. Cardiac injury was detected in 150 (24.7%) of patients included in the study. Mortality rate was higher in patients with cardiac injury (42% vs. 8%; P < 0.01). The frequency of patients who required ICU (72% vs. 19%), who developed acute kidney injury (14% vs. 1%) and acute respiratory distress syndrome (71%vs. 18%) were also higher in patients with cardiac injury. In multivariate analysis, age, coronary artery disease (CAD), elevated CRP levels, and presence of cardiac injury [odds ratio (OR) 10.58, 95% confidence interval (CI) 2.42-46.27; P < 0.001) were found to be independent predictors of mortality. In subgroup analysis, including patients free of history of CAD, presence of cardiac injury on admission also predicted mortality (OR 2.52, 95% CI 1.17-5.45; P = 0.018). CONCLUSION: Cardiac injury on admission is associated with worse clinical outcome and higher mortality risk in COVID-19 patients including patients free of previous CAD diagnosis. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Biomarkers/blood[MESH] |COVID-19/blood/*diagnosis/mortality/therapy[MESH] |Coronary Artery Disease/blood/*diagnosis/mortality/therapy[MESH] |Disease Progression[MESH] |Female[MESH] |Heart Diseases/blood/*diagnosis/mortality/therapy[MESH] |Hospital Mortality[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Patient Admission[MESH] |Predictive Value of Tests[MESH] |Retrospective Studies[MESH] |Risk Assessment[MESH] |Risk Factors[MESH] |Time Factors[MESH] |Troponin I/*blood[MESH] |Turkey[MESH]Prognostic significance of cardiac injury in COVID-19 patients with an(epmc).pdf DeepDyve Pubget Overpricing