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10.3390/ijms20143548 http://scihub22266oqcxt.onion/10.3390/ijms20143548 32565533!6678548!32565533     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2019 ; 20 (14): ä Nephropedia Template TP {{tp|p=32565533|t=2019. Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3 |pdf=|usr=}}{{32565533}} gab.com Text Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3 JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32565533 #FOAvip In both monoclonal gammopathy of uncertain significance (MGUS) and multiple myeloma (MM) patients, immune functions are variably impaired, and there is a high risk of bacterial infections. Neutrophils are the most abundant circulating leukocytes and constitute the first line of host defense. Since little is known about the contribution of autophagy in the neutrophil function of MGUS and MM patients, we investigated the basal autophagy flux in freshly sorted neutrophils of patients and tested the plastic response of healthy neutrophils to soluble factors of MM. In freshly sorted high-density neutrophils obtained from patients with MGUS and MM or healthy subjects, we found a progressive autophagy trigger associated with soluble factors circulating in both peripheral blood and bone marrow, associated with increased IFNgamma and pSTAT3S727. In normal high-density neutrophils, the formation of acidic vesicular organelles, a morphological characteristic of autophagy, could be induced after exposure for three hours with myeloma conditioned media or MM sera, an effect associated with increased phosphorylation of STAT3-pS727 and reverted by treatment with pan-JAK2 inhibitor ruxolitinib. Taken together, our data suggest that soluble factors in MM can trigger contemporary JAK2 signaling and autophagy in neutrophils, targetable with ruxolitinib. Twit Text FOAVip Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3 ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32565533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32565533 #FOAvip English Wikipedia <ref>{{Cite pmid|32565533}}</ref> Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3 #MMPMID32565533 Puglisi F; Parrinello NL; Giallongo C; Cambria D; Camiolo G; Bellofiore C; Conticello C; Del Fabro V; Leotta V; Markovic U; Sapienza G; Barbato A; Scalese S; Tibullo D; Brundo MV; Palumbo GA; Di Raimondo F; Romano A Int J Mol Sci 2019[Jul]; 20 (14): ä PMID32565533show ga In both monoclonal gammopathy of uncertain significance (MGUS) and multiple myeloma (MM) patients, immune functions are variably impaired, and there is a high risk of bacterial infections. Neutrophils are the most abundant circulating leukocytes and constitute the first line of host defense. Since little is known about the contribution of autophagy in the neutrophil function of MGUS and MM patients, we investigated the basal autophagy flux in freshly sorted neutrophils of patients and tested the plastic response of healthy neutrophils to soluble factors of MM. In freshly sorted high-density neutrophils obtained from patients with MGUS and MM or healthy subjects, we found a progressive autophagy trigger associated with soluble factors circulating in both peripheral blood and bone marrow, associated with increased IFNgamma and pSTAT3S727. In normal high-density neutrophils, the formation of acidic vesicular organelles, a morphological characteristic of autophagy, could be induced after exposure for three hours with myeloma conditioned media or MM sera, an effect associated with increased phosphorylation of STAT3-pS727 and reverted by treatment with pan-JAK2 inhibitor ruxolitinib. Taken together, our data suggest that soluble factors in MM can trigger contemporary JAK2 signaling and autophagy in neutrophils, targetable with ruxolitinib. |Aged[MESH] |Autophagy/drug effects[MESH] |Cell Movement/drug effects[MESH] |Cell Proliferation/drug effects[MESH] |Culture Media, Conditioned/metabolism/pharmacology[MESH] |Female[MESH] |Gene Expression Regulation, Neoplastic/drug effects[MESH] |Humans[MESH] |Interferon-gamma/*genetics[MESH] |Janus Kinase 2/antagonists & inhibitors/*genetics[MESH] |Male[MESH] |Middle Aged[MESH] |Monoclonal Gammopathy of Undetermined Significance/drug therapy/metabolism/pathology[MESH] |Multiple Myeloma/*drug therapy/metabolism/pathology[MESH] |Neutrophils/*drug effects/metabolism/pathology[MESH] |Nitriles[MESH] |Phosphorylation/drug effects[MESH] |Pyrazoles/pharmacology[MESH] |Pyrimidines[MESH] |Reactive Oxygen Species/metabolism[MESH] |STAT3 Transcription Factor/*genetics[MESH]Plasticity of High-Density Neutrophils in Multiple Myeloma is Associat(epmc).pdf DeepDyve Pubget Overpricing