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10.1016/j.mehy.2020.109976

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109976
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32563970!7276125!32563970
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suck abstract from ncbi


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pmid32563970      Med+Hypotheses 2020 ; 144 (ä): 109976
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  • Deceiving SARS-CoV-2 molecular-tropism clues - A combinational contemporary strategy #MMPMID32563970
  • Balaji A; Bhuvaneswari S; Kumar DN
  • Med Hypotheses 2020[Nov]; 144 (ä): 109976 PMID32563970show ga
  • Several attempts to control the dreadfulness of SARS-CoV-2 are still underway. Based on the literature evidences we have speculated a prospective contemporary remedy, which was categorized into Specificity, Remedy, and a Conveyor. In which, pros and cons were discussed and inferred the possible alternatives. (a) Specificity: Implicit to express the ACE2 receptors in conveyor cells to deceive SARS-CoV-2 frompreponetargets. (b) Remedy: As depletion of pulmonary surfactants causes strong acute respiratory distress syndrome, we propose an entity of a cost-effective artificialsurfactantsystem as a remedy to pulmonary complications. (c) Conveyor: We propose red blood cells (RBCs) as a conveyor with embedded artificial surfactant and protruding ACE2 receptors for the target-specific delivery. Overall we postulate focused insights by employing a combinational contemporary strategy to steer towards a prospective direction on combating SARS-CoV-2.
  • |*Erythrocytes[MESH]
  • |*Viral Tropism[MESH]
  • |Angiotensin-Converting Enzyme 2/administration & dosage/*therapeutic use[MESH]
  • |COVID-19/complications/prevention & control/*virology[MESH]
  • |Drug Costs[MESH]
  • |Drug Delivery Systems[MESH]
  • |Humans[MESH]
  • |Pulmonary Alveoli/drug effects/virology[MESH]
  • |Pulmonary Surfactants/administration & dosage/chemical synthesis/economics/*therapeutic use[MESH]
  • |Receptors, Virus/administration & dosage/*therapeutic use[MESH]
  • |Respiratory Distress Syndrome/prevention & control[MESH]


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