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10.1016/j.jaut.2020.102506

http://scihub22266oqcxt.onion/10.1016/j.jaut.2020.102506
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32563547!7296326!32563547
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suck abstract from ncbi


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pmid32563547      J+Autoimmun 2020 ; 114 (ä): 102506
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  • Autoinflammatory and autoimmune conditions at the crossroad of COVID-19 #MMPMID32563547
  • Rodriguez Y; Novelli L; Rojas M; De Santis M; Acosta-Ampudia Y; Monsalve DM; Ramirez-Santana C; Costanzo A; Ridgway WM; Ansari AA; Gershwin ME; Selmi C; Anaya JM
  • J Autoimmun 2020[Nov]; 114 (ä): 102506 PMID32563547show ga
  • Coronavirus disease 2019 (COVID-19) has been categorized as evolving in overlapping phases. First, there is a viral phase that may well be asymptomatic or mild in the majority, perhaps 80% of patients. The pathophysiological mechanisms resulting in minimal disease in this initial phase are not well known. In the remaining 20% of cases, the disease may become severe and/or critical. In most patients of this latter group, there is a phase characterized by the hyperresponsiveness of the immune system. A third phase corresponds to a state of hypercoagulability. Finally, in the fourth stage organ injury and failure occur. Appearance of autoinflammatory/autoimmune phenomena in patients with COVID-19 calls attention for the development of new strategies for the management of life-threatening conditions in critically ill patients. Antiphospholipid syndrome, autoimmune cytopenia, Guillain-Barre syndrome and Kawasaki disease have each been reported in patients with COVID-19. Here we present a scoping review of the relevant immunological findings in COVID-19 as well as the current reports about autoinflammatory/autoimmune conditions associated with the disease. These observations have crucial therapeutic implications since immunomodulatory drugs are at present the most likely best candidates for COVID-19 therapy. Clinicians should be aware of these conditions in patients with COVID-19, and these observations should be considered in the current development of vaccines.
  • |Adaptive Immunity/genetics[MESH]
  • |Autoimmune Diseases/diagnosis/*immunology/therapy/virology[MESH]
  • |Betacoronavirus/*immunology/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/diagnosis/epidemiology/*immunology/therapy[MESH]
  • |Critical Illness[MESH]
  • |Cytokine Release Syndrome/diagnosis/*immunology/therapy/virology[MESH]
  • |Female[MESH]
  • |Genetic Predisposition to Disease[MESH]
  • |Humans[MESH]
  • |Immunity, Innate/genetics[MESH]
  • |Immunization, Passive/methods[MESH]
  • |Inflammation Mediators/blood/immunology[MESH]
  • |Macrophage Activation/genetics/immunology[MESH]
  • |Male[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/epidemiology/*immunology/therapy[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Severity of Illness Index[MESH]


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