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10.1016/j.pharmthera.2020.107613

http://scihub22266oqcxt.onion/10.1016/j.pharmthera.2020.107613
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32562826!ä!32562826

suck abstract from ncbi


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pmid32562826      Pharmacol+Ther 2020 ; 214 (ä): 107613
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  • Therapeutic potential of resveratrol against emerging respiratory viral infections #MMPMID32562826
  • Filardo S; Di Pietro M; Mastromarino P; Sessa R
  • Pharmacol Ther 2020[Oct]; 214 (ä): 107613 PMID32562826show ga
  • Resveratrol has been widely studied for its therapeutic potential due to its antioxidant, anti-inflammatory and anti-microbial properties. In particular, resveratrol has shown promising antiviral activity against numerous viruses responsible for severe respiratory infections. Amongst these, influenza virus, respiratory syncytial virus and the emerging SARS-cov-2 are known to cause pneumonia, acute respiratory distress syndrome or multi-organ failure, especially, in vulnerable individuals like immunocompromised patients or the elderly, leading to a considerable economic burden worldwide. In this context, resveratrol may have potential value for its anti-inflammatory activity, since most of the severe virus-associated complications are related to the overactivation of the host-immune response, leading to lung damage. Herein, we present an overview of the antiviral activity and potential mechanisms of resveratrol against the respiratory tract viruses considered as a public threat for their rapid transmission and high morbidity and mortality in the general population.
  • |Antiviral Agents/pharmacokinetics/*pharmacology/*therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Communicable Diseases, Emerging/drug therapy[MESH]
  • |Coronavirus Infections/drug therapy[MESH]
  • |Humans[MESH]
  • |Influenza, Human/drug therapy[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy[MESH]
  • |Respiratory Syncytial Virus Infections/drug therapy[MESH]
  • |Respiratory Tract Infections/*drug therapy/virology[MESH]
  • |Resveratrol/pharmacokinetics/*pharmacology/*therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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