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10.1096/fj.202001351 http://scihub22266oqcxt.onion/10.1096/fj.202001351 32562316!7323129!32562316     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       FASEB+J 2020 ; 34 (8): 9832-9842 Nephropedia Template TP {{tp|p=32562316|t=2020. A proposed role for the SARS-CoV-2 nucleocapsid protein in the formation and regulation of biomolecular condensates |pdf=|usr=}}{{32562316}} gab.com Text A proposed role for the SARS-CoV-2 nucleocapsid protein in the formation and regulation of biomolecular condensates JO: FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32562316 #FOAvip To date, the recently discovered SARS-CoV-2 virus has afflicted >6.9 million people worldwide and disrupted the global economy. Development of effective vaccines or treatments for SARS-CoV-2 infection will be aided by a molecular-level understanding of SARS-CoV-2 proteins and their interactions with host cell proteins. The SARS-CoV-2 nucleocapsid (N) protein is highly homologous to the N protein of SARS-CoV, which is essential for viral RNA replication and packaging into new virions. Emerging models indicate that nucleocapsid proteins of other viruses can form biomolecular condensates to spatiotemporally regulate N protein localization and function. Our bioinformatic analyses, in combination with pre-existing experimental evidence, suggest that the SARS-CoV-2 N protein is capable of forming or regulating biomolecular condensates in vivo by interaction with RNA and key host cell proteins. We discuss multiple models, whereby the N protein of SARS-CoV-2 may harness this activity to regulate viral life cycle and host cell response to viral infection. Twit Text FOAVip A proposed role for the SARS-CoV-2 nucleocapsid protein in the formation and regulation of biomolecular condensates ????FASEB J http://www.kidney.de/pget.php?&tw=1&pmid=32562316 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32562316 #FOAvip English Wikipedia <ref>{{Cite pmid|32562316}}</ref> A proposed role for the SARS-CoV-2 nucleocapsid protein in the formation and regulation of biomolecular condensates #MMPMID32562316 Cascarina SM; Ross ED FASEB J 2020[Aug]; 34 (8): 9832-9842 PMID32562316show ga To date, the recently discovered SARS-CoV-2 virus has afflicted >6.9 million people worldwide and disrupted the global economy. Development of effective vaccines or treatments for SARS-CoV-2 infection will be aided by a molecular-level understanding of SARS-CoV-2 proteins and their interactions with host cell proteins. The SARS-CoV-2 nucleocapsid (N) protein is highly homologous to the N protein of SARS-CoV, which is essential for viral RNA replication and packaging into new virions. Emerging models indicate that nucleocapsid proteins of other viruses can form biomolecular condensates to spatiotemporally regulate N protein localization and function. Our bioinformatic analyses, in combination with pre-existing experimental evidence, suggest that the SARS-CoV-2 N protein is capable of forming or regulating biomolecular condensates in vivo by interaction with RNA and key host cell proteins. We discuss multiple models, whereby the N protein of SARS-CoV-2 may harness this activity to regulate viral life cycle and host cell response to viral infection. |Binding Sites[MESH] |Computational Biology[MESH] |Coronavirus Nucleocapsid Proteins/*chemistry[MESH] |Cytoplasmic Granules/chemistry[MESH] |Humans[MESH] |Phosphoproteins/chemistry[MESH] |Protein Binding[MESH] |Protein Domains[MESH] |Protein Kinases/chemistry[MESH] |SARS-CoV-2/*chemistry/physiology[MESH] |Virus Assembly[MESH]A proposed role for the SARS-CoV-2 nucleocapsid protein in the formati(epmc).pdf DeepDyve Pubget Overpricing