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10.1111/bph.15166 http://scihub22266oqcxt.onion/10.1111/bph.15166 32562276!7323198!32562276     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2020 ; 177 (21): 4873-4886 Nephropedia Template TP {{tp|p=32562276|t=2020. Statins: Could an old friend help in the fight against COVID-19?|pdf=|usr=}}{{32562276}} gab.com Text Statins: Could an old friend help in the fight against COVID-19 JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32562276 #FOAvip The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overwhelmed healthcare systems requiring the rapid development of treatments, at least, to reduce COVID-19 severity. Drug repurposing offers a fast track. Here, we discuss the potential beneficial effects of statins in COVID-19 patients based on evidence that they may target virus receptors, replication, degradation, and downstream responses in infected cells, addressing both basic research and epidemiological information. Briefly, statins could modulate virus entry, acting on the SARS-CoV-2 receptors, ACE2 and CD147, and/or lipid rafts engagement. Statins, by inducing autophagy activation, could regulate virus replication or degradation, exerting protective effects. The well-known anti-inflammatory properties of statins, by blocking several molecular mechanisms, including NF-kappaB and NLRP3 inflammasomes, could limit the "cytokine storm" in severe COVID-19 patients which is linked to fatal outcome. Finally, statin moderation of coagulation response activation may also contribute to improving COVID-19 outcomes. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. Twit Text FOAVip Statins: Could an old friend help in the fight against COVID-19 ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32562276 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32562276 #FOAvip English Wikipedia <ref>{{Cite pmid|32562276}}</ref> Statins: Could an old friend help in the fight against COVID-19? #MMPMID32562276 Rodrigues-Diez RR; Tejera-Munoz A; Marquez-Exposito L; Rayego-Mateos S; Santos Sanchez L; Marchant V; Tejedor Santamaria L; Ramos AM; Ortiz A; Egido J; Ruiz-Ortega M Br J Pharmacol 2020[Nov]; 177 (21): 4873-4886 PMID32562276show ga The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has overwhelmed healthcare systems requiring the rapid development of treatments, at least, to reduce COVID-19 severity. Drug repurposing offers a fast track. Here, we discuss the potential beneficial effects of statins in COVID-19 patients based on evidence that they may target virus receptors, replication, degradation, and downstream responses in infected cells, addressing both basic research and epidemiological information. Briefly, statins could modulate virus entry, acting on the SARS-CoV-2 receptors, ACE2 and CD147, and/or lipid rafts engagement. Statins, by inducing autophagy activation, could regulate virus replication or degradation, exerting protective effects. The well-known anti-inflammatory properties of statins, by blocking several molecular mechanisms, including NF-kappaB and NLRP3 inflammasomes, could limit the "cytokine storm" in severe COVID-19 patients which is linked to fatal outcome. Finally, statin moderation of coagulation response activation may also contribute to improving COVID-19 outcomes. LINKED ARTICLES: This article is part of a themed issue on The Pharmacology of COVID-19. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.21/issuetoc. |Animals[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/*drug therapy/immunology/virology[MESH] |Cytokines/immunology[MESH] |Drug Repositioning[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage/pharmacology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/immunology/virology[MESH] |SARS-CoV-2[MESH]Statins: Could an old friend help in the fight against COVID-19?(epmc).pdf DeepDyve Pubget Overpricing