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10.1016/j.ejphar.2020.173288 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173288 32561291!7297682!32561291     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2020 ; 882 (ä): 173288 Nephropedia Template TP {{tp|p=32561291|t=2020. Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management?|pdf=|usr=}}{{32561291}} gab.com Text Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32561291 #FOAvip In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection. Twit Text FOAVip Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32561291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32561291 #FOAvip English Wikipedia <ref>{{Cite pmid|32561291}}</ref> Endoplasmic reticulum as a potential therapeutic target for covid-19 infection management? #MMPMID32561291 Sureda A; Alizadeh J; Nabavi SF; Berindan-Neagoe I; Cismaru CA; Jeandet P; Los MJ; Clementi E; Nabavi SM; Ghavami S Eur J Pharmacol 2020[Sep]; 882 (ä): 173288 PMID32561291show ga In December 2019, many pneumonia cases with unidentified sources appeared in Wuhan, Hubei, China, with clinical symptoms like viral pneumonia. Deep sequencing analysis of samples from lower respiratory tract revealed a novel coronavirus, called 2019 novel coronavirus (2019-nCoV). Currently there is a rapid global spread. World Health Organization declare the disease a pandemic condition. The pathologic source of this disease was a new RNA virus from Coronaviridae family, which was named COVID-19. SARS-CoV-2 entry starts with the binding of the spike glycoprotein expressed on the viral envelope to ACE2 on the alveolar surface followed by clathrin-dependent endocytosis of the SARS-CoV-2 and ACE2 complex. SARS-CoV-2 enters the cells through endocytosis process, which is possibly facilitated, via a pH dependent endosomal cysteine protease cathepsins. Once inside the cells, SARS-CoV-2 exploits the endogenous transcriptional machinery of alveolar cells to replicate and spread through the entire lung. Endosomal acidic pH for SARS-CoV-2 processing and internalization is critical. After entering the cells, it possibly activates or hijack many intracellular pathways in favor of its replication. In the current opinion article, we will explain the possible involvement of unfolded protein response as a cellular stress response to the SARS-CoV-2 infection. |Alveolar Epithelial Cells/cytology/*drug effects/metabolism/virology[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/metabolism[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Clathrin-Coated Vesicles/drug effects/metabolism[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Endocytosis/drug effects[MESH] |Endoplasmic Reticulum/*drug effects/metabolism[MESH] |Endosomes/drug effects/metabolism[MESH] |Humans[MESH] |Ionophores/*pharmacology/therapeutic use[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |SARS-CoV-2[MESH]Endoplasmic reticulum as a potential therapeutic target for covid-19 i(epmc).pdf DeepDyve Pubget Overpricing