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10.1016/j.immuni.2020.06.001

http://scihub22266oqcxt.onion/10.1016/j.immuni.2020.06.001
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32561270!7276322!32561270
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suck abstract from ncbi


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pmid32561270      Immunity 2020 ; 53 (1): 98-105.e5
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  • Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation #MMPMID32561270
  • Seydoux E; Homad LJ; MacCamy AJ; Parks KR; Hurlburt NK; Jennewein MF; Akins NR; Stuart AB; Wan YH; Feng J; Whaley RE; Singh S; Boeckh M; Cohen KW; McElrath MJ; Englund JA; Chu HY; Pancera M; McGuire AT; Stamatatos L
  • Immunity 2020[Jul]; 53 (1): 98-105.e5 PMID32561270show ga
  • Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes, and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein spike (S) from a COVID-19-infected subject 21 days after the onset of clinical disease. 45 S-specific monoclonal antibodies were generated. They had undergone minimal somatic mutation with limited clonal expansion, and three bound the receptor-binding domain (RBD). Two antibodies neutralized SARS-CoV-2. The most potent antibody bound the RBD and prevented binding to the ACE2 receptor, while the other bound outside the RBD. Thus, most anti-S antibodies that were generated in this patient during the first weeks of COVID-19 infection were non-neutralizing and target epitopes outside the RBD. Antibodies that disrupt the SARS-CoV-2 S-ACE2 interaction can potently neutralize the virus without undergoing extensive maturation. Such antibodies have potential preventive and/or therapeutic potential and can serve as templates for vaccine design.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Antibodies, Monoclonal/immunology[MESH]
  • |Antibodies, Neutralizing/*immunology[MESH]
  • |Antibodies, Viral/*immunology[MESH]
  • |B-Lymphocytes/immunology[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |Binding Sites[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/immunology/prevention & control[MESH]
  • |Epitopes, B-Lymphocyte/immunology[MESH]
  • |Humans[MESH]
  • |Pandemics/prevention & control[MESH]
  • |Peptidyl-Dipeptidase A/metabolism[MESH]
  • |Pneumonia, Viral/immunology/prevention & control[MESH]
  • |Protein Binding[MESH]
  • |Receptors, Virus/metabolism[MESH]
  • |SARS-CoV-2[MESH]
  • |Somatic Hypermutation, Immunoglobulin/*genetics[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology/metabolism[MESH]


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