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10.1186/s13054-020-03060-9 http://scihub22266oqcxt.onion/10.1186/s13054-020-03060-9 32560665!7303575!32560665     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32560665&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Crit+Care 2020 ; 24 (1): 365 Nephropedia Template TP {{tp|p=32560665|t=2020. "War to the knife" against thromboinflammation to protect endothelial function of COVID-19 patients |pdf=|usr=}}{{32560665}} gab.com Text "War to the knife" against thromboinflammation to protect endothelial function of COVID-19 patients JO: Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=32560665 #FOAvip In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction, with a focus on direct viral infection and cytokine-mediated injury. Entanglement between inflammation and coagulation and resistance to heparin provide a rationale to consider other therapeutic approaches in order to preserve endothelial function and limit microthrombosis, especially in severe forms. These strategies include nebulized heparin, N-acetylcysteine, plasma exchange and/or fresh frozen plasma, plasma derivatives to increase the level of endogenous anticoagulants (tissue factor pathway inhibitor, activated protein C, thrombomodulin, antithrombin), dipyridamole, complement blockers, different types of stem cells, and extracellular vesicles. An integrated therapy including these drugs has the potential to improve outcomes in COVID-19. Twit Text FOAVip "War to the knife" against thromboinflammation to protect endothelial function of COVID-19 patients ????Crit Care http://www.kidney.de/pget.php?&tw=1&pmid=32560665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32560665 #FOAvip English Wikipedia <ref>{{Cite pmid|32560665}}</ref> "War to the knife" against thromboinflammation to protect endothelial function of COVID-19 patients #MMPMID32560665 Guglielmetti G; Quaglia M; Sainaghi PP; Castello LM; Vaschetto R; Pirisi M; Corte FD; Avanzi GC; Stratta P; Cantaluppi V Crit Care 2020[Jun]; 24 (1): 365 PMID32560665show ga In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction, with a focus on direct viral infection and cytokine-mediated injury. Entanglement between inflammation and coagulation and resistance to heparin provide a rationale to consider other therapeutic approaches in order to preserve endothelial function and limit microthrombosis, especially in severe forms. These strategies include nebulized heparin, N-acetylcysteine, plasma exchange and/or fresh frozen plasma, plasma derivatives to increase the level of endogenous anticoagulants (tissue factor pathway inhibitor, activated protein C, thrombomodulin, antithrombin), dipyridamole, complement blockers, different types of stem cells, and extracellular vesicles. An integrated therapy including these drugs has the potential to improve outcomes in COVID-19. |COVID-19[MESH] |Coronavirus Infections/physiopathology/*therapy[MESH] |Endothelial Cells/*physiology[MESH] |Humans[MESH] |Inflammation/*prevention & control[MESH] |Pandemics[MESH] |Pneumonia, Viral/physiopathology/*therapy[MESH]"War to the knife" against thromboinflammation to protect endothelial (epmc).pdf DeepDyve Pubget Overpricing