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10.1177/1040638720934809

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suck abstract from ncbi


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pmid32560597      J+Vet+Diagn+Invest 2020 ; 32 (4): 598-603
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  • Molecular evidence for vaccine-induced canine distemper virus and canine adenovirus 2 coinfection in a fennec fox #MMPMID32560597
  • Tamukai K; Minami S; Kurihara R; Shimoda H; Mitsui I; Maeda K; Une Y
  • J Vet Diagn Invest 2020[Jul]; 32 (4): 598-603 PMID32560597show ga
  • A 61-d-old fennec fox (Vulpes zerda), 11 d after receiving a multivalent, modified-live virus vaccine containing canine distemper virus (CDV), canine adenovirus 2 (CAdV-2), parainfluenza virus, parvovirus, and canine coronavirus, developed oculonasal discharge, and subsequently convulsions, and hemoptysis, and died. Microscopic changes in the cerebrum were evident, including neuronal degeneration and necrosis; intracytoplasmic eosinophilic inclusion bodies were observed in astrocytes. CDV was detected in the brain tissue by immunohistochemistry. Pulmonary lesions of multifocal necrotizing bronchopneumonia had Cowdry type A intranuclear inclusions in the bronchial epithelial cells. Electron microscopy revealed crystalline arrays of adenovirus-like particles within the intranuclear inclusions. Additionally, the hemagglutinin gene of CDV and the CAdV-2 DNA polymerase gene were detected in the fennec fox; sequence analysis showed 100% identity with those of the vaccine strain viruses. To our knowledge, vaccine-induced CDV and CAdV-2 coinfections using molecular analysis have not been reported previously. Therefore, vaccine strains should be considered prior to CDV vaccination in nondomestic carnivores.
  • |Adenoviridae Infections/*veterinary/virology[MESH]
  • |Adenoviruses, Canine/*isolation & purification[MESH]
  • |Animals[MESH]
  • |Brain/virology[MESH]
  • |Coinfection/*veterinary[MESH]
  • |Distemper Virus, Canine/genetics/*isolation & purification[MESH]
  • |Distemper/virology[MESH]
  • |Fatal Outcome[MESH]
  • |Foxes/*virology[MESH]
  • |Parvoviridae Infections/veterinary/virology[MESH]
  • |Vaccination/veterinary[MESH]
  • |Vaccines, Attenuated[MESH]


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