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10.3390/molecules25122784

http://scihub22266oqcxt.onion/10.3390/molecules25122784
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32560203!7356203!32560203
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suck abstract from ncbi


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pmid32560203      Molecules 2020 ; 25 (12): ä
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  • Quinoxaline Derivatives as Antiviral Agents: A Systematic Review #MMPMID32560203
  • Montana M; Montero V; Khoumeri O; Vanelle P
  • Molecules 2020[Jun]; 25 (12): ä PMID32560203show ga
  • BACKGROUND: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry. OBJECTIVES: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives. METHODS: Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020. RESULTS: A final total of 20 studies included in this review. CONCLUSIONS: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Betacoronavirus/*drug effects[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy[MESH]
  • |DNA Viruses/drug effects[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy[MESH]
  • |Quinoxalines/chemistry/*therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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