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10.1055/a-1185-8913 http://scihub22266oqcxt.onion/10.1055/a-1185-8913 32559771!7417290!32559771     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Res+(Stuttg) 2020 ; 70 (8): 337-340 Nephropedia Template TP {{tp|p=32559771|t=2020. The Battle against COVID 19 Pandemic: What we Need to Know Before we "Test Fire" Ivermectin |pdf=|usr=}}{{32559771}} gab.com Text The Battle against COVID 19 Pandemic: What we Need to Know Before we "Test Fire" Ivermectin JO: Drug Res (Stuttg) http://www.kidney.de/pget.php?&tw=1&pmid=32559771 #FOAvip The world is faced with the dire challenge of finding an effective treatment against the rampaging COVID 19 pandemic. Amidst the crisis, reports of in vitro inhibitory activity of ivermectin, an approved anthelmintic, against the causative SARSCoV2 virus, have generated lot of optimism. In this article, we have fished and compiled the needed information on the drug, that will help readers and prospective investigators in having a quick overview. Though the primordial biological action of the drug is allosteric modulation of helminthic ion channel receptor, its in vitro activity against both RNA and DNA viruses is known for almost a decade. In the past two years, efficacy study in animal models of pseudorabies and zika virus was found to be favourable and unfavourable respectively. Only one clinical study evaluated the drug in dengue virus infection without any clinical efficacy. However, the proposed mechanism of drug action, by inhibiting the importin family of nucleus-cytoplasmic transporters along with favourable pharmacokinetics, warrants exploration of its role in COVID 19 through safely conducted clinical trials. Being an available and affordable drug, enlisted in WHO List of Essential Medicine, and a long track record of clinical safety, the drug is already in clinical trials the world over. As the pandemic continues to ravage human civilisation with unabated intensity, the world eagerly waits for a ray of hope emanating from the outcome of the ongoing trials with ivermectin as well as other drugs. Twit Text FOAVip The Battle against COVID 19 Pandemic: What we Need to Know Before we "Test Fire" Ivermectin ????Drug Res (Stuttg) http://www.kidney.de/pget.php?&tw=1&pmid=32559771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32559771 #FOAvip English Wikipedia <ref>{{Cite pmid|32559771}}</ref> The Battle against COVID 19 Pandemic: What we Need to Know Before we "Test Fire" Ivermectin #MMPMID32559771 Banerjee K; Nandy M; Dalai CK; Ahmed SN Drug Res (Stuttg) 2020[Aug]; 70 (8): 337-340 PMID32559771show ga The world is faced with the dire challenge of finding an effective treatment against the rampaging COVID 19 pandemic. Amidst the crisis, reports of in vitro inhibitory activity of ivermectin, an approved anthelmintic, against the causative SARSCoV2 virus, have generated lot of optimism. In this article, we have fished and compiled the needed information on the drug, that will help readers and prospective investigators in having a quick overview. Though the primordial biological action of the drug is allosteric modulation of helminthic ion channel receptor, its in vitro activity against both RNA and DNA viruses is known for almost a decade. In the past two years, efficacy study in animal models of pseudorabies and zika virus was found to be favourable and unfavourable respectively. Only one clinical study evaluated the drug in dengue virus infection without any clinical efficacy. However, the proposed mechanism of drug action, by inhibiting the importin family of nucleus-cytoplasmic transporters along with favourable pharmacokinetics, warrants exploration of its role in COVID 19 through safely conducted clinical trials. Being an available and affordable drug, enlisted in WHO List of Essential Medicine, and a long track record of clinical safety, the drug is already in clinical trials the world over. As the pandemic continues to ravage human civilisation with unabated intensity, the world eagerly waits for a ray of hope emanating from the outcome of the ongoing trials with ivermectin as well as other drugs. |Animals[MESH] |Antiviral Agents/chemistry/economics/pharmacology/*therapeutic use[MESH] |Betacoronavirus/*drug effects/genetics[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Ivermectin/chemistry/economics/pharmacology/*therapeutic use[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH]The Battle against COVID 19 Pandemic: What we Need to Know Before we "(epmc).pdf DeepDyve Pubget Overpricing