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10.1093/infdis/jiaa350

http://scihub22266oqcxt.onion/10.1093/infdis/jiaa350
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32559285!7337790!32559285
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suck abstract from ncbi


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pmid32559285      J+Infect+Dis 2020 ; 222 (5): 722-725
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  • Interferon-beta-1a Inhibition of Severe Acute Respiratory Syndrome-Coronavirus 2 In Vitro When Administered After Virus Infection #MMPMID32559285
  • Clementi N; Ferrarese R; Criscuolo E; Diotti RA; Castelli M; Scagnolari C; Burioni R; Antonelli G; Clementi M; Mancini N
  • J Infect Dis 2020[Aug]; 222 (5): 722-725 PMID32559285show ga
  • The ongoing coronavirus disease 2019 pandemic has forced the clinical and scientific community to try drug repurposing of existing antiviral agents as a quick option against severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Under this scenario, interferon (IFN) beta-1a, whose antiviral potential is already known, and which is a drug currently used in the clinical management of multiple sclerosis, may represent as a potential candidate. In this report, we demonstrate that IFN-beta-1a was highly effective in inhibiting in vitro SARS-CoV-2 replication at clinically achievable concentration when administered after virus infection.
  • |Animals[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |Betacoronavirus/*drug effects/physiology[MESH]
  • |COVID-19[MESH]
  • |Chlorocebus aethiops[MESH]
  • |Coronavirus Infections/*drug therapy/*virology[MESH]
  • |Drug Repositioning[MESH]
  • |Interferon beta-1a/*pharmacology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/*virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Vero Cells[MESH]


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