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10.1002/jmv.26208

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32558955!7323441!32558955
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suck abstract from ncbi


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pmid32558955      J+Med+Virol 2021 ; 93 (1): 234-240
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  • The clinical characteristics of pediatric inpatients with SARS-CoV-2 infection: A meta-analysis and systematic review #MMPMID32558955
  • Ma X; Liu S; Chen L; Zhuang L; Zhang J; Xin Y
  • J Med Virol 2021[Jan]; 93 (1): 234-240 PMID32558955show ga
  • Millions of people were infected with the coronavirus disease 2019 (COVID-19) all over the world. Data on clinical symptoms of pediatric inpatients with COVID-19 infection were unclear. The aim of study was to investigate the clinical features of pediatric inpatients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. PubMed, EMBASE, and the Cochrane Library were searched to seek for studies providing details on pediatric inpatients with SARS-CoV-2 infection which were published from 1st January to 21st April 2020. Studies with more than five pediatric inpatients were included in our meta-analysis.This study was registered in the PROSPERO database (CRD42020183550). As the results shown, fever (46%) and cough (42%) were the main clinical characters of pediatric inpatients with SARS-CoV-2 infection and the other clinical characters, such as diarrhea, vomiting, nasal congestion, and fatigue account for 10% in pediatric inpatients. The proportion of asymptomatic cases was 0.42 (95% confidence interval [CI]: 0.27-0.59) and severe cases was 0.03 (95% CI: 0.01-0.06). For the laboratory result, leukopenia (21%) and lymphocytosis (22%) were the mainly indicators for pediatric inpatients, followed by high aspartate aminotransferase (19%), lymphopenia (16%), high alanine aminotransferase (15%), high C-reactive protein (17%), leukocytosis (13%), high D-dimer (12%) and high creatine kinase-MB (5%). Regard to chest imaging features, unilateral and bilateral accounts for 22% in pediatric inpatients, respectively. In conclusion, compared with adult inpatients with SARS-CoV-2 infection, the pediatric inpatients had mild clinical characters, lab test indicators, and chest imaging features. More clinical studies focus on the pediatric patients with SARS-CoV-2 infection in other countries should be conducted.
  • |COVID-19/blood/*diagnosis/*physiopathology[MESH]
  • |Child[MESH]
  • |Cough/virology[MESH]
  • |Fever/virology[MESH]
  • |Humans[MESH]
  • |Inpatients[MESH]
  • |Observational Studies as Topic[MESH]
  • |Thorax/diagnostic imaging/virology[MESH]


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