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10.1002/psp4.12543 http://scihub22266oqcxt.onion/10.1002/psp4.12543 32558354!7323384!32558354     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       CPT+Pharmacometrics+Syst+Pharmacol 2020 ; 9 (9): 509-514 Nephropedia Template TP {{tp|p=32558354|t=2020. Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load |pdf=|usr=}}{{32558354}} gab.com Text Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load JO: CPT Pharmacometrics Syst Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32558354 #FOAvip We modeled the viral dynamics of 13 untreated patients infected with severe acute respiratory syndrome-coronavirus 2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than two logs, drug efficacy needs to be > 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6-87% efficacy. They may help control virus if administered very early, but may not have a major effect in severely ill patients. Twit Text FOAVip Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load ????CPT Pharmacometrics Syst Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32558354 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32558354 #FOAvip English Wikipedia <ref>{{Cite pmid|32558354}}</ref> Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-CoV-2 Viral Load #MMPMID32558354 Goncalves A; Bertrand J; Ke R; Comets E; de Lamballerie X; Malvy D; Pizzorno A; Terrier O; Rosa Calatrava M; Mentre F; Smith P; Perelson AS; Guedj J CPT Pharmacometrics Syst Pharmacol 2020[Sep]; 9 (9): 509-514 PMID32558354show ga We modeled the viral dynamics of 13 untreated patients infected with severe acute respiratory syndrome-coronavirus 2 to infer viral growth parameters and predict the effects of antiviral treatments. In order to reduce peak viral load by more than two logs, drug efficacy needs to be > 90% if treatment is administered after symptom onset; an efficacy of 60% could be sufficient if treatment is initiated before symptom onset. Given their pharmacokinetic/pharmacodynamic properties, current investigated drugs may be in a range of 6-87% efficacy. They may help control virus if administered very early, but may not have a major effect in severely ill patients. |*COVID-19 Drug Treatment[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Humans[MESH] |Lopinavir/pharmacology/therapeutic use[MESH] |Models, Theoretical[MESH] |Ritonavir/pharmacology/therapeutic use[MESH] |SARS-CoV-2/drug effects/*physiology[MESH] |Severity of Illness Index[MESH] |Singapore[MESH] |Treatment Outcome[MESH]Timing of Antiviral Treatment Initiation is Critical to Reduce SARS-Co(epmc).pdf DeepDyve Pubget Overpricing