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10.1002/mgg3.1344 http://scihub22266oqcxt.onion/10.1002/mgg3.1344 32558308!7323111!32558308     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Genet+Genomic+Med 2020 ; 8 (8): e1344 Nephropedia Template TP {{tp|p=32558308|t=2020. Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations |pdf=|usr=}}{{32558308}} gab.com Text Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations JO: Mol Genet Genomic Med http://www.kidney.de/pget.php?&tw=1&pmid=32558308 #FOAvip BACKGROUND: There appears to be large regional variation for susceptibility, severity, and mortality for COVID-19 infections. Numerous potential factors could explain the wide variability in the number of infections and death among the countries. We examined genetic differences in the human angiotensin-converting enzyme 2 (hACE2) gene, as its receptor serves as a cellular entry for SARS-CoV-2. At present, there is a paucity of data regarding the differences for ACE2 polymorphisms and expression levels between ethnicities. METHODS: We compared the allele frequency of mutations between European and East Asians. Molecular dynamic simulation were performed to investigate the influences of significant mutant on protein structure. The binding free energies were calculated between S protein and hACE2. We also examined hACE2 gene expression in eight global populations from HapMap3. RESULTS: Four missense mutations showed significant minor allele frequency difference between Asians and Caucasians. Molecular dynamic demonstrated that two of these variants (K26R and I468V) may affect binding characteristics between S protein of the virus and hACE2 receptor. We also noted marginal differences in gene expression for some populations in HapMap3 as compared to the Chinese population. CONCLUSION: Our studies reveal subtle changes in the genetics of hACE2 between human populations, but the magnitude of the difference was small and the significance is not clear in the absence of further in vitro and functional studies. Twit Text FOAVip Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations ????Mol Genet Genomic Med http://www.kidney.de/pget.php?&tw=1&pmid=32558308 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32558308 #FOAvip English Wikipedia <ref>{{Cite pmid|32558308}}</ref> Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations #MMPMID32558308 Li Q; Cao Z; Rahman P Mol Genet Genomic Med 2020[Aug]; 8 (8): e1344 PMID32558308show ga BACKGROUND: There appears to be large regional variation for susceptibility, severity, and mortality for COVID-19 infections. Numerous potential factors could explain the wide variability in the number of infections and death among the countries. We examined genetic differences in the human angiotensin-converting enzyme 2 (hACE2) gene, as its receptor serves as a cellular entry for SARS-CoV-2. At present, there is a paucity of data regarding the differences for ACE2 polymorphisms and expression levels between ethnicities. METHODS: We compared the allele frequency of mutations between European and East Asians. Molecular dynamic simulation were performed to investigate the influences of significant mutant on protein structure. The binding free energies were calculated between S protein and hACE2. We also examined hACE2 gene expression in eight global populations from HapMap3. RESULTS: Four missense mutations showed significant minor allele frequency difference between Asians and Caucasians. Molecular dynamic demonstrated that two of these variants (K26R and I468V) may affect binding characteristics between S protein of the virus and hACE2 receptor. We also noted marginal differences in gene expression for some populations in HapMap3 as compared to the Chinese population. CONCLUSION: Our studies reveal subtle changes in the genetics of hACE2 between human populations, but the magnitude of the difference was small and the significance is not clear in the absence of further in vitro and functional studies. |*Polymorphism, Genetic[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Asian People/genetics[MESH] |Betacoronavirus/isolation & purification/metabolism[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Coronavirus Infections/pathology/virology[MESH] |Gene Frequency[MESH] |Humans[MESH] |Molecular Dynamics Simulation[MESH] |Mutation, Missense[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/chemistry/*genetics/metabolism[MESH] |Pneumonia, Viral/pathology/virology[MESH] |Protein Binding[MESH] |Protein Structure, Tertiary[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/chemistry/metabolism[MESH]Genetic variability of human angiotensin-converting enzyme 2 (hACE2) a(epmc).pdf DeepDyve Pubget Overpricing