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10.1084/jem.20201000

http://scihub22266oqcxt.onion/10.1084/jem.20201000
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32556101!7301648!32556101
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suck abstract from ncbi


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pmid32556101      J+Exp+Med 2020 ; 217 (8): ä
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  • The renin-angiotensin system: An integrated view of lung disease and coagulopathy in COVID-19 and therapeutic implications #MMPMID32556101
  • Diamond B
  • J Exp Med 2020[Aug]; 217 (8): ä PMID32556101show ga
  • The renin-angiotensin system (RAS) has long been appreciated as a major regulator of blood pressure, but has more recently been recognized as a mechanism for modulating inflammation as well. While there has been concern in COVID-19 patients over the use of drugs that target this system, the RAS has not been explored fully as a druggable target. The abbreviated description of the RAS suggests that its dysregulation may be at the center of COVID-19.
  • |Angiotensin I/metabolism[MESH]
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Blood Coagulation Disorders/virology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/etiology/metabolism/*physiopathology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Humans[MESH]
  • |Hypertension/physiopathology[MESH]
  • |Lung Diseases/metabolism/*physiopathology/virology[MESH]
  • |Lung/metabolism/physiopathology/*virology[MESH]
  • |Obesity/physiopathology[MESH]
  • |Pandemics[MESH]
  • |Peptide Fragments/metabolism[MESH]
  • |Peptidyl-Dipeptidase A/metabolism[MESH]
  • |Pneumonia, Viral/etiology/metabolism/*physiopathology[MESH]
  • |Receptor, Angiotensin, Type 1/metabolism[MESH]


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