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10.1172/jci.insight.140711 http://scihub22266oqcxt.onion/10.1172/jci.insight.140711 32554923!7455060!32554923     free     free     free       JCI+Insight 2020 ; 5 (15): ä Nephropedia Template TP {{tp|p=32554923|t=2020. The complement system in COVID-19: friend and foe?|pdf=|usr=}}{{32554923}} gab.com Text The complement system in COVID-19: friend and foe JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=32554923 #FOAvip Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality have been attributed to an exaggerated immune response. The role of complement activation and its contribution to illness severity is being increasingly recognized. Here, we summarize current knowledge about the interaction of coronaviruses with the complement system. We posit that (a) coronaviruses activate multiple complement pathways; (b) severe COVID-19 clinical features often resemble complementopathies; (c) the combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19; (d) a subset of patients with COVID-19 may have a genetic predisposition associated with complement dysregulation; and (e) these observations create a basis for clinical trials of complement inhibitors in life-threatening illness. Twit Text FOAVip The complement system in COVID-19: friend and foe ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=32554923 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32554923 #FOAvip English Wikipedia <ref>{{Cite pmid|32554923}}</ref> The complement system in COVID-19: friend and foe? #MMPMID32554923 Java A; Apicelli AJ; Liszewski MK; Coler-Reilly A; Atkinson JP; Kim AH; Kulkarni HS JCI Insight 2020[Aug]; 5 (15): ä PMID32554923show ga Coronavirus disease 2019 (COVID-19), the disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in a global pandemic and a disruptive health crisis. COVID-19-related morbidity and mortality have been attributed to an exaggerated immune response. The role of complement activation and its contribution to illness severity is being increasingly recognized. Here, we summarize current knowledge about the interaction of coronaviruses with the complement system. We posit that (a) coronaviruses activate multiple complement pathways; (b) severe COVID-19 clinical features often resemble complementopathies; (c) the combined effects of complement activation, dysregulated neutrophilia, endothelial injury, and hypercoagulability appear to be intertwined to drive the severe features of COVID-19; (d) a subset of patients with COVID-19 may have a genetic predisposition associated with complement dysregulation; and (e) these observations create a basis for clinical trials of complement inhibitors in life-threatening illness. |*Betacoronavirus/pathogenicity/physiology[MESH] |*Coronavirus Infections/blood/immunology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/blood/immunology[MESH] |Blood Coagulation[MESH] |COVID-19[MESH] |Complement Activation/*immunology[MESH] |Endothelial Cells/virology[MESH] |Humans[MESH]The complement system in COVID-19: friend and foe?(epmc).pdf DeepDyve Pubget Overpricing