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10.1007/s12038-020-00053-2 http://scihub22266oqcxt.onion/10.1007/s12038-020-00053-2 32554907!7291183!32554907     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biosci 2020 ; 45 (1): ä Nephropedia Template TP {{tp|p=32554907|t=2020. Current global vaccine and drug efforts against COVID-19: Pros and cons of bypassing animal trials |pdf=|usr=}}{{32554907}} gab.com Text Current global vaccine and drug efforts against COVID-19: Pros and cons of bypassing animal trials JO: J Biosci http://www.kidney.de/pget.php?&tw=1&pmid=32554907 #FOAvip COVID-19 has become one of the biggest health concern, along with huge economic burden. With no clear remedies to treat the disease, doctors are repurposing drugs like chloroquine and remdesivir to treat COVID-19 patients. In parallel, research institutes in collaboration with biotech companies have identified strategies to use viral proteins as vaccine candidates for COVID-19. Although this looks promising, they still need to pass the test of challenge studies in animal models. As various models for SARS-CoV-2 are under testing phase, biotech companies have bypassed animal studies and moved to Phase I clinical trials. In view of the present outbreak, this looks a justified approach, but the problem is that in the absence of animal studies, we can never predict the outcomes in humans. Since animal models are critical for vaccine development and SARS-CoV-2 has different transmission dynamics, in this review we compare different animal models of SARS-CoV-2 with humans for their pathogenic, immune response and transmission dynamics that make them ideal models for vaccine testing for COVID-19. Another issue of using animal model is the ethics of using animals for research; thus, we also discuss the pros and cons of using animals for vaccine development studies. Twit Text FOAVip Current global vaccine and drug efforts against COVID-19: Pros and cons of bypassing animal trials ????J Biosci http://www.kidney.de/pget.php?&tw=1&pmid=32554907 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32554907 #FOAvip English Wikipedia <ref>{{Cite pmid|32554907}}</ref> Current global vaccine and drug efforts against COVID-19: Pros and cons of bypassing animal trials #MMPMID32554907 Deb B; Shah H; Goel S J Biosci 2020[]; 45 (1): ä PMID32554907show ga COVID-19 has become one of the biggest health concern, along with huge economic burden. With no clear remedies to treat the disease, doctors are repurposing drugs like chloroquine and remdesivir to treat COVID-19 patients. In parallel, research institutes in collaboration with biotech companies have identified strategies to use viral proteins as vaccine candidates for COVID-19. Although this looks promising, they still need to pass the test of challenge studies in animal models. As various models for SARS-CoV-2 are under testing phase, biotech companies have bypassed animal studies and moved to Phase I clinical trials. In view of the present outbreak, this looks a justified approach, but the problem is that in the absence of animal studies, we can never predict the outcomes in humans. Since animal models are critical for vaccine development and SARS-CoV-2 has different transmission dynamics, in this review we compare different animal models of SARS-CoV-2 with humans for their pathogenic, immune response and transmission dynamics that make them ideal models for vaccine testing for COVID-19. Another issue of using animal model is the ethics of using animals for research; thus, we also discuss the pros and cons of using animals for vaccine development studies. |*Animal Experimentation[MESH] |*Models, Animal[MESH] |*Viral Vaccines[MESH] |Animals[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/*immunology[MESH] |Humans[MESH] |Pandemics[MESH]Current global vaccine and drug efforts against COVID-19: Pros and con(epmc).pdf DeepDyve Pubget Overpricing