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  • Treatment strategies of hospitalized patients with coronavirus disease-19 #MMPMID32554861
  • Huang Y; Cai C; Zang J; Xie J; Xu D; Zheng F; Zhan T; Huang K; Wang Y; Wang X; Hu ZY; Deng Y; Xie Y
  • Aging (Albany NY) 2020[Jun]; 12 (12): 11224-11237 PMID32554861show ga
  • With the outbreak of coronavirus disease-19 (COVID-19), Changsha faced an increasing burden of treating the Wuhan migrants and their infected patients. This study is a retrospective, single-center case series of the 238 consecutive hospitalized patients with confirmed COVID-19 at the First Hospital of Changsha city, China, from 01/21 to 02/14, 2020; the final date of follow-up was 02/27, 2020. Of 238 patients 43.7% visited Wuhan, 58.4% got in touch with Wuhan people, and 47.5% had contacted with diagnosed patients. 37.8% patients had family members infected. 190 cases had mild / general disease, and 48 cases had severe / critical disease. Compared to mild or general patients, more severe or critical patients visited Wuhan (59.6% vs 40.2%; P=0.02) and contacted with Wuhan people (74.5% vs 55.0%; P=0.02). All patients received antiviral treatment, including Lopinavir / Ritonavir (29.3%), Interferon (14.6%) and their combination (40.6%), Arbidol (6.7%), Xuebijing (7.1%) and Chloroquine phosphate (1.3%). Severe and critical patients received glucocorticoid, Gamma-globulin and oxygen inhalation. Some received mechanic ventilation support. As of 02/27, 161 patients discharged. The median length of hospital stay was 13 days. The 10-, 14-, 20- and 28-day discharge rate was 19.1%, 42.8%, 65.0% and 76.4%, respectively. No hospital-related transmission was observed.
  • |*Betacoronavirus[MESH]
  • |*Respiration, Artificial[MESH]
  • |Adult[MESH]
  • |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |China/epidemiology[MESH]
  • |Chloroquine/analogs & derivatives/therapeutic use[MESH]
  • |Coronavirus Infections/*epidemiology/*therapy[MESH]
  • |Drug Combinations[MESH]
  • |Drugs, Chinese Herbal/therapeutic use[MESH]
  • |Female[MESH]
  • |Glucocorticoids/therapeutic use[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Immunologic Factors/therapeutic use[MESH]
  • |Indoles/therapeutic use[MESH]
  • |Interferons/therapeutic use[MESH]
  • |Lopinavir/therapeutic use[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oxygen/therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*epidemiology/*therapy[MESH]
  • |Retrospective Studies[MESH]
  • |Ritonavir/therapeutic use[MESH]
  • |gamma-Globulins/therapeutic use[MESH]

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  • suck abstract from ncbi

    11224 12.12 2020