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10.1016/j.mehy.2020.109984 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109984 32554149!7286248!32554149     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 144 (ä): 109984 Nephropedia Template TP {{tp|p=32554149|t=2020. Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy |pdf=|usr=}}{{32554149}} gab.com Text Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32554149 #FOAvip In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen. Twit Text FOAVip Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32554149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32554149 #FOAvip English Wikipedia <ref>{{Cite pmid|32554149}}</ref> Aminoglycosides can be a better choice over macrolides in COVID-19 regimen: Plausible mechanism for repurposing strategy #MMPMID32554149 Chalichem NSS; Bethapudi B; Mundkinajeddu D Med Hypotheses 2020[Nov]; 144 (ä): 109984 PMID32554149show ga In the current COVID-19 pandemic, prioritizing the immunity enhancers is equally important to anti-virals. Defensins are the forgotten molecules that enhance the innate immunity against various microbes. Although macrolides like azithromycin and clarithromycin etc., have been reported to act against respiratory infections but they lack the ability of immunity enhancement through defensins. The aminoglycosides were proved to have defensin mediated antiviral activity, that could enhance the immunity. So, Consideration of aminoglycosides can be a double edge sword viz., against respiratory infection as well as Immunity enhancer (along with anti-virals) for COVID-19 regimen. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |Aminoglycosides/pharmacology/*therapeutic use[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |COVID-19/epidemiology/immunology[MESH] |Codon, Nonsense/drug effects[MESH] |Defensins/biosynthesis/*genetics/physiology[MESH] |Humans[MESH] |Immunity, Innate/*drug effects[MESH] |Immunologic Factors/pharmacology/*therapeutic use[MESH] |Macrolides/*therapeutic use[MESH] |Models, Genetic[MESH] |Pandemics[MESH] |SARS-CoV-2/physiology[MESH] |Transcription, Genetic/drug effects[MESH]Aminoglycosides can be a better choice over macrolides in COVID-19 reg(epmc).pdf DeepDyve Pubget Overpricing