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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Semin+Cell+Dev+Biol 2021 ; 111 (ä): 101-107 Nephropedia Template TP
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An Arms Race between the Nonsense-mediated mRNA Decay Pathway and Viral Infections #MMPMID32553580
Leon K; Ott M
Semin Cell Dev Biol 2021[Mar]; 111 (ä): 101-107 PMID32553580show ga
The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis.