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10.1016/j.cell.2020.06.011 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.06.011 32553273!7284254!32553273     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 182 (3): 744-753.e4 Nephropedia Template TP {{tp|p=32553273|t=2020. A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies |pdf=|usr=}}{{32553273}} gab.com Text A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32553273 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of potential therapies and vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is the lack of susceptible small animals in large numbers. Commercially available laboratory strains of mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Here, we transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues. hACE2-transduced mice were productively infected with SARS-CoV-2, and this resulted in high viral titers in the lung, lung pathology, and weight loss. Passive transfer of a neutralizing monoclonal antibody reduced viral burden in the lung and mitigated inflammation and weight loss. The development of an accessible mouse model of SARS-CoV-2 infection and pathogenesis will expedite the testing and deployment of therapeutics and vaccines. Twit Text FOAVip A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32553273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32553273 #FOAvip English Wikipedia <ref>{{Cite pmid|32553273}}</ref> A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies #MMPMID32553273 Hassan AO; Case JB; Winkler ES; Thackray LB; Kafai NM; Bailey AL; McCune BT; Fox JM; Chen RE; Alsoussi WB; Turner JS; Schmitz AJ; Lei T; Shrihari S; Keeler SP; Fremont DH; Greco S; McCray PB Jr; Perlman S; Holtzman MJ; Ellebedy AH; Diamond MS Cell 2020[Aug]; 182 (3): 744-753.e4 PMID32553273show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic with millions of human infections. One limitation to the evaluation of potential therapies and vaccines to inhibit SARS-CoV-2 infection and ameliorate disease is the lack of susceptible small animals in large numbers. Commercially available laboratory strains of mice are not readily infected by SARS-CoV-2 because of species-specific differences in their angiotensin-converting enzyme 2 (ACE2) receptors. Here, we transduced replication-defective adenoviruses encoding human ACE2 via intranasal administration into BALB/c mice and established receptor expression in lung tissues. hACE2-transduced mice were productively infected with SARS-CoV-2, and this resulted in high viral titers in the lung, lung pathology, and weight loss. Passive transfer of a neutralizing monoclonal antibody reduced viral burden in the lung and mitigated inflammation and weight loss. The development of an accessible mouse model of SARS-CoV-2 infection and pathogenesis will expedite the testing and deployment of therapeutics and vaccines. |*Disease Models, Animal[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Antibodies, Monoclonal/*therapeutic use[MESH] |Antibodies, Neutralizing/*therapeutic use[MESH] |Antibodies, Viral/*therapeutic use[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*therapy/virology[MESH] |Female[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunization, Passive/methods[MESH] |Lung/metabolism/virology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Mice, Inbred C57BL[MESH] |Mice, Inbred DBA[MESH] |Mice, Knockout[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics/metabolism[MESH] |Pneumonia, Viral/*therapy/virology[MESH] |SARS-CoV-2[MESH] |Transduction, Genetic[MESH] |Vero Cells[MESH]A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutra(epmc).pdf DeepDyve Pubget Overpricing