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10.1016/j.celrep.2020.107772 http://scihub22266oqcxt.onion/10.1016/j.celrep.2020.107772 32553163!7297157!32553163     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2020 ; 31 (11): 107772 Nephropedia Template TP {{tp|p=32553163|t=2020. Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins |pdf=|usr=}}{{32553163}} gab.com Text Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32553163 #FOAvip ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-gamma release from natural killer (NK) and T cells. The signals that lead to the production of extracellular ISG15 and the relationship between its two core functions remain unclear. We show that both epithelial cells and lymphocytes can secrete ISG15, which then signals in either an autocrine or paracrine manner to LFA-1-expressing cells. Microbial pathogens and Toll-like receptor (TLR) agonists result in both IFN-beta-dependent and -independent secretion of ISG15, and residues required for ISG15 secretion are mapped. Intracellular ISGylation inhibits secretion, and viral effector proteins, influenza B NS1, and viral de-ISGylases, including SARS-CoV-2 PL(pro), have opposing effects on secretion of ISG15. These results establish extracellular ISG15 as a cytokine-like protein that bridges early innate and IFN-gamma-dependent immune responses, and indicate that pathogens have evolved to differentially inhibit the intracellular and extracellular functions of ISG15. Twit Text FOAVip Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=32553163 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32553163 #FOAvip English Wikipedia <ref>{{Cite pmid|32553163}}</ref> Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins #MMPMID32553163 Swaim CD; Canadeo LA; Monte KJ; Khanna S; Lenschow DJ; Huibregtse JM Cell Rep 2020[Jun]; 31 (11): 107772 PMID32553163show ga ISG15 is a ubiquitin-like modifier that also functions extracellularly, signaling through the LFA-1 integrin to promote interferon (IFN)-gamma release from natural killer (NK) and T cells. The signals that lead to the production of extracellular ISG15 and the relationship between its two core functions remain unclear. We show that both epithelial cells and lymphocytes can secrete ISG15, which then signals in either an autocrine or paracrine manner to LFA-1-expressing cells. Microbial pathogens and Toll-like receptor (TLR) agonists result in both IFN-beta-dependent and -independent secretion of ISG15, and residues required for ISG15 secretion are mapped. Intracellular ISGylation inhibits secretion, and viral effector proteins, influenza B NS1, and viral de-ISGylases, including SARS-CoV-2 PL(pro), have opposing effects on secretion of ISG15. These results establish extracellular ISG15 as a cytokine-like protein that bridges early innate and IFN-gamma-dependent immune responses, and indicate that pathogens have evolved to differentially inhibit the intracellular and extracellular functions of ISG15. |*Signal Transduction[MESH] |Animals[MESH] |Cytokines/*metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Influenza, Human/immunology/metabolism[MESH] |Interferon-gamma/immunology/metabolism[MESH] |Jurkat Cells[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mycobacterium Infections/immunology/metabolism[MESH] |Pathogen-Associated Molecular Pattern Molecules[MESH] |Typhoid Fever/immunology/metabolism[MESH] |Ubiquitins/*metabolism[MESH]Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Eff(epmc).pdf DeepDyve Pubget Overpricing