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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Euro+Surveill 2020 ; 25 (23): ä Nephropedia Template TP
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Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications #MMPMID32553061
Caini S; Bellerba F; Corso F; Diaz-Basabe A; Natoli G; Paget J; Facciotti F; De Angelis SP; Raimondi S; Palli D; Mazzarella L; Pelicci PG; Vineis P; Gandini S
Euro Surveill 2020[Jun]; 25 (23): ä PMID32553061show ga
We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with = 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be = 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.