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10.1186/s12985-020-01347-5 http://scihub22266oqcxt.onion/10.1186/s12985-020-01347-5 32552831!7298446!32552831     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virol+J 2020 ; 17 (1): 77 Nephropedia Template TP {{tp|p=32552831|t=2020. Challenge infection model for MERS-CoV based on naturally infected camels |pdf=|usr=}}{{32552831}} gab.com Text Challenge infection model for MERS-CoV based on naturally infected camels JO: Virol J http://www.kidney.de/pget.php?&tw=1&pmid=32552831 #FOAvip BACKGROUND: Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging virus that infects humans and camels with no approved antiviral therapy or vaccine. Some vaccines are in development for camels as a one-health intervention where vaccinating camels is proposed to reduce human viral exposure. This intervention will require an understanding of the prior exposure of camels to the virus and appropriate vaccine efficacy studies in camels. METHODS: We conducted a cross sectional seroprevalence study in young dromedary camels to determine the rate of MERS-CoV seropositivity in young camels. Next, we utilised naturally infected camels as a natural challenge model that can be used by co-housing these camels with healthy naive camels in a ratio of 1 to 2. This model is aimed to support studies on natural virus transmission as well as evaluating drug and vaccine efficacy. RESULTS: We found that 90% of the screened camels have pre-existing antibodies for MERS-CoV. In addition, the challenge model resulted in MERS-CoV transmission within 48 h with infections that continued for 14 days post challenge. CONCLUSIONS: Our finding suggests that the majority of young dromedary camels in Saudi Arabia are seropositive and that naturally infected camels can serve as a challenge model to assess transmission, therapeutics, and vaccine efficacy. Twit Text FOAVip Challenge infection model for MERS-CoV based on naturally infected camels ????Virol J http://www.kidney.de/pget.php?&tw=1&pmid=32552831 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32552831 #FOAvip English Wikipedia <ref>{{Cite pmid|32552831}}</ref> Challenge infection model for MERS-CoV based on naturally infected camels #MMPMID32552831 Alharbi NK; Ibrahim OH; Alhafufi A; Kasem S; Aldowerij A; Albrahim R; Abu-Obaidah A; Alkarar A; Bayoumi FA; Almansour AM; Aldubaib M; Al-Abdely HM; Balkhy HH; Qasim I Virol J 2020[Jun]; 17 (1): 77 PMID32552831show ga BACKGROUND: Middle East Respiratory Syndrome coronavirus (MERS-CoV) is an emerging virus that infects humans and camels with no approved antiviral therapy or vaccine. Some vaccines are in development for camels as a one-health intervention where vaccinating camels is proposed to reduce human viral exposure. This intervention will require an understanding of the prior exposure of camels to the virus and appropriate vaccine efficacy studies in camels. METHODS: We conducted a cross sectional seroprevalence study in young dromedary camels to determine the rate of MERS-CoV seropositivity in young camels. Next, we utilised naturally infected camels as a natural challenge model that can be used by co-housing these camels with healthy naive camels in a ratio of 1 to 2. This model is aimed to support studies on natural virus transmission as well as evaluating drug and vaccine efficacy. RESULTS: We found that 90% of the screened camels have pre-existing antibodies for MERS-CoV. In addition, the challenge model resulted in MERS-CoV transmission within 48 h with infections that continued for 14 days post challenge. CONCLUSIONS: Our finding suggests that the majority of young dromedary camels in Saudi Arabia are seropositive and that naturally infected camels can serve as a challenge model to assess transmission, therapeutics, and vaccine efficacy. |*Disease Models, Animal[MESH] |Animals[MESH] |Antibodies, Viral/blood[MESH] |Camelus/*virology[MESH] |Coronavirus Infections/epidemiology/prevention & control/transmission/*veterinary[MESH] |Cross-Sectional Studies[MESH] |Middle East Respiratory Syndrome Coronavirus/*immunology[MESH] |Saudi Arabia/epidemiology[MESH] |Seroepidemiologic Studies[MESH]Challenge infection model for MERS-CoV based on naturally infected cam(epmc).pdf DeepDyve Pubget Overpricing