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10.1637/0005-2086-64.2.183

http://scihub22266oqcxt.onion/10.1637/0005-2086-64.2.183
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32550619!ä!32550619

suck abstract from ncbi


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pmid32550619      Avian+Dis 2020 ; 64 (2): 183-196
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  • Genetic, Antigenic, and Pathogenic Characteristics of Infectious Bronchitis Virus GI-7/TW-II in China #MMPMID32550619
  • Ren M; Zhang L; Hou Y; Zhao Y; Han Z; Sun J; Liu S
  • Avian Dis 2020[Jun]; 64 (2): 183-196 PMID32550619show ga
  • Nine infectious bronchitis virus (IBV) strains belonging to the GI-7 lineage were isolated between 2009 and 2017 in China. Phylogenetic analysis and comparisons of full-length sequences of the S1 gene suggested that the GI-7 lineage should be further classified as Taiwan (TW)-I and TW-II sublineages, which correspond to the previous TW-I and TW-II genotypes. The nine IBV strains were clustered in the TW-II sublineage. Further investigation revealed that viruses in the TW-I and TW-II were not only genetically but also antigenically different. Moreover, the TW-II sublineage contained various clades and recombinants. A recombinant was found to originate from recombination events between field strains (TW-II ck/CH/LJL/090608- and GI-19 ck/ CH/LDL/091022-like viruses) in which the recombination in the S1 subunit coding sequences had led to changes in antigenicity of the viruses. A more in-depth investigation demonstrated that TW-II viruses appear to have undergone a significant evolution following introduction in mainland China, which resulted in the viruses diverging into different clades. The viruses between the different clades in TW-II sublineage exhibited a significant change in genetic and antigenic characteristics. In addition, the five TW-II viruses selected on the basis of the results of S1 nucleotide sequence phylogenetic trees showed different pathogenicity to specific-pathogen-free chickens, although they could induce nephritis in the infected chickens and thus were identified as nephropathogenic strains.
  • |*Chickens[MESH]
  • |*Infectious bronchitis virus/genetics/immunology/pathogenicity[MESH]
  • |Amino Acid Sequence[MESH]
  • |Animals[MESH]
  • |Antigens, Viral/genetics/metabolism[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*veterinary/virology[MESH]
  • |Phylogeny[MESH]
  • |Poultry Diseases/*virology[MESH]
  • |Sequence Alignment[MESH]
  • |Specific Pathogen-Free Organisms[MESH]


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