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10.1007/s00228-020-02933-w http://scihub22266oqcxt.onion/10.1007/s00228-020-02933-w 32548679!7297510!32548679     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32548679&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Clin+Pharmacol 2020 ; 76 (10): 1471-1472 Nephropedia Template TP {{tp|p=32548679|t=2020. Calling for an exponential escalation scheme in vaccine development for COVID-19 |pdf=|usr=}}{{32548679}} gab.com Text Calling for an exponential escalation scheme in vaccine development for COVID-19 JO: Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32548679 #FOAvip PURPOSE: COVID-19 as a pandemic calls for rapid development of vaccines. METHODS: Here a proposal of a seamless, adaptive, phase 1-3 trial for accelerated vaccine development is described. RESULTS: Starting at 10, the number of vaccinated volunteers would exponentially increase by tenfold at an interval of 2 weeks; close surveillance of antibody responses, safety and efficacy is necessary. After only 16 weeks, general vaccination would be feasible if supply meets the demand. CONCLUSION: A COVID-19 vaccine would be rapidly available at a slightly increased risk for undetected late side effects or insufficient efficacy if compared with standard vaccine development schemes. Twit Text FOAVip Calling for an exponential escalation scheme in vaccine development for COVID-19 ????Eur J Clin Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=32548679 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32548679 #FOAvip English Wikipedia <ref>{{Cite pmid|32548679}}</ref> Calling for an exponential escalation scheme in vaccine development for COVID-19 #MMPMID32548679 Wehling M Eur J Clin Pharmacol 2020[Oct]; 76 (10): 1471-1472 PMID32548679show ga PURPOSE: COVID-19 as a pandemic calls for rapid development of vaccines. METHODS: Here a proposal of a seamless, adaptive, phase 1-3 trial for accelerated vaccine development is described. RESULTS: Starting at 10, the number of vaccinated volunteers would exponentially increase by tenfold at an interval of 2 weeks; close surveillance of antibody responses, safety and efficacy is necessary. After only 16 weeks, general vaccination would be feasible if supply meets the demand. CONCLUSION: A COVID-19 vaccine would be rapidly available at a slightly increased risk for undetected late side effects or insufficient efficacy if compared with standard vaccine development schemes. |*Viral Vaccines[MESH] |Betacoronavirus[MESH] |Biomedical Research/*organization & administration[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Clinical Trials as Topic/organization & administration[MESH] |Coronavirus Infections/*prevention & control[MESH] |Humans[MESH] |Pandemics/*prevention & control[MESH] |Pneumonia, Viral/*prevention & control[MESH]Calling for an exponential escalation scheme in vaccine development fo(epmc).pdf DeepDyve Pubget Overpricing