Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1126/sciadv.aaz5466

http://scihub22266oqcxt.onion/10.1126/sciadv.aaz5466
suck pdf from google scholar
32548259!7274527!32548259
unlimited free pdf from europmc32548259    free
PDF from PMC    free
html from PMC    free

suck abstract from ncbi


Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534

Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
pmid32548259      Sci+Adv 2020 ; 6 (23): eaaz5466
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Squalene-based multidrug nanoparticles for improved mitigation of uncontrolled inflammation in rodents #MMPMID32548259
  • Dormont F; Brusini R; Cailleau C; Reynaud F; Peramo A; Gendron A; Mougin J; Gaudin F; Varna M; Couvreur P
  • Sci Adv 2020[Jun]; 6 (23): eaaz5466 PMID32548259show ga
  • Uncontrolled inflammatory processes are at the root of numerous pathologies. Most recently, studies on confirmed COVID-19 cases have suggested that mortality might be due to virally induced hyperinflammation. Uncontrolled pro-inflammatory states are often driven by continuous positive feedback loops between pro-inflammatory signaling and oxidative stress, which cannot be resolved in a targeted manner. Here, we report on the development of multidrug nanoparticles for the mitigation of uncontrolled inflammation. The nanoparticles are made by conjugating squalene, a natural lipid, to adenosine, an endogenous immunomodulator, and then encapsulating alpha-tocopherol, as antioxidant. This resulted in high drug loading, biocompatible, multidrug nanoparticles. By exploiting the endothelial dysfunction at sites of acute inflammation, these multidrug nanoparticles delivered the therapeutic agents in a targeted manner, conferring survival advantage to treated animals in models of endotoxemia. Selectively delivering adenosine and antioxidants together could serve as a novel therapeutic approach for safe treatment of acute paradoxal inflammation.
  • |Adenosine/administration & dosage/chemistry[MESH]
  • |Animals[MESH]
  • |Antioxidants/administration & dosage/chemistry[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/drug therapy/pathology/virology[MESH]
  • |Disease Models, Animal[MESH]
  • |Drug Delivery Systems/*methods[MESH]
  • |Endotoxemia/chemically induced/*drug therapy[MESH]
  • |Female[MESH]
  • |Immunologic Factors/administration & dosage/chemistry[MESH]
  • |Lipopolysaccharides/pharmacology[MESH]
  • |Male[MESH]
  • |Mice[MESH]
  • |Mice, Inbred BALB C[MESH]
  • |Mice, Inbred C57BL[MESH]
  • |Nanoparticles/administration & dosage/*chemistry[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/pathology/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Squalene/administration & dosage/*chemistry[MESH]
  • |Systemic Inflammatory Response Syndrome/chemically induced/*drug therapy[MESH]
  • |Treatment Outcome[MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box