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10.1080/19420862.2020.1782600

http://scihub22266oqcxt.onion/10.1080/19420862.2020.1782600
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suck abstract from ncbi


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pmid32546047      MAbs 2020 ; 12 (1): e1782600
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  • Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic #MMPMID32546047
  • Qian K; Hu S
  • MAbs 2020[Jan]; 12 (1): e1782600 PMID32546047show ga
  • While the potential therapeutic utility of angiotensin-converting enzyme 2 (ACE2) is well established, the clinical development of ACE2 drugs has been limited, likely due in part to the short half-life of the protein. In contrast, Ig-like ACE2 fusion proteins have exhibited greatly extended plasma half-life in vivo, and they have been shown to have a potent neutralization effect against SARS-CoV-2. Clinical investigation of Ig-like ACE2 fusion proteins as COVID-19 interventions is thus warranted.
  • |Angiotensin-Converting Enzyme 2[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/adverse effects/*therapeutic use[MESH]
  • |Betacoronavirus/*drug effects/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/diagnosis/*drug therapy/immunology/virology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Immunoglobulin Fc Fragments/adverse effects/*therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Peptidyl-Dipeptidase A/adverse effects/*therapeutic use[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy/immunology/virology[MESH]
  • |Recombinant Fusion Proteins/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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