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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 MAbs 2020 ; 12 (1): e1782600 Nephropedia Template TP
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Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic #MMPMID32546047
Qian K; Hu S
MAbs 2020[Jan]; 12 (1): e1782600 PMID32546047show ga
While the potential therapeutic utility of angiotensin-converting enzyme 2 (ACE2) is well established, the clinical development of ACE2 drugs has been limited, likely due in part to the short half-life of the protein. In contrast, Ig-like ACE2 fusion proteins have exhibited greatly extended plasma half-life in vivo, and they have been shown to have a potent neutralization effect against SARS-CoV-2. Clinical investigation of Ig-like ACE2 fusion proteins as COVID-19 interventions is thus warranted.