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10.3390/v12060642 http://scihub22266oqcxt.onion/10.3390/v12060642 32545799!7354438!32545799     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2020 ; 12 (6): ä Nephropedia Template TP {{tp|p=32545799|t=2020. Potential Antiviral Options against SARS-CoV-2 Infection |pdf=|usr=}}{{32545799}} gab.com Text Potential Antiviral Options against SARS-CoV-2 Infection JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32545799 #FOAvip As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United Nations (UN) has highlighted the need for better control of SARS-CoV-2 infections. However, developing novel virus-specific vaccines, monoclonal antibodies and antiviral drugs against SARS-CoV-2 can be time-consuming and costly. Convalescent sera and safe-in-man broad-spectrum antivirals (BSAAs) are readily available treatment options. Here, we developed a neutralization assay using SARS-CoV-2 strain and Vero-E6 cells. We identified the most potent sera from recovered patients for the treatment of SARS-CoV-2-infected patients. We also screened 136 safe-in-man broad-spectrum antivirals against the SARS-CoV-2 infection in Vero-E6 cells and identified nelfinavir, salinomycin, amodiaquine, obatoclax, emetine and homoharringtonine. We found that a combination of orally available virus-directed nelfinavir and host-directed amodiaquine exhibited the highest synergy. Finally, we developed a website to disseminate the knowledge on available and emerging treatments of COVID-19. Twit Text FOAVip Potential Antiviral Options against SARS-CoV-2 Infection ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=32545799 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32545799 #FOAvip English Wikipedia <ref>{{Cite pmid|32545799}}</ref> Potential Antiviral Options against SARS-CoV-2 Infection #MMPMID32545799 Ianevski A; Yao R; Fenstad MH; Biza S; Zusinaite E; Reisberg T; Lysvand H; Loseth K; Landsem VM; Malmring JF; Oksenych V; Erlandsen SE; Aas PA; Hagen L; Pettersen CH; Tenson T; Afset JE; Nordbo SA; Bjoras M; Kainov DE Viruses 2020[Jun]; 12 (6): ä PMID32545799show ga As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United Nations (UN) has highlighted the need for better control of SARS-CoV-2 infections. However, developing novel virus-specific vaccines, monoclonal antibodies and antiviral drugs against SARS-CoV-2 can be time-consuming and costly. Convalescent sera and safe-in-man broad-spectrum antivirals (BSAAs) are readily available treatment options. Here, we developed a neutralization assay using SARS-CoV-2 strain and Vero-E6 cells. We identified the most potent sera from recovered patients for the treatment of SARS-CoV-2-infected patients. We also screened 136 safe-in-man broad-spectrum antivirals against the SARS-CoV-2 infection in Vero-E6 cells and identified nelfinavir, salinomycin, amodiaquine, obatoclax, emetine and homoharringtonine. We found that a combination of orally available virus-directed nelfinavir and host-directed amodiaquine exhibited the highest synergy. Finally, we developed a website to disseminate the knowledge on available and emerging treatments of COVID-19. |Amodiaquine/pharmacology[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects[MESH] |COVID-19[MESH] |COVID-19 Serotherapy[MESH] |Caco-2 Cells[MESH] |Cell Line, Tumor[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/*drug therapy/therapy[MESH] |Drug Therapy, Combination[MESH] |Emetine/pharmacology[MESH] |HEK293 Cells[MESH] |HT29 Cells[MESH] |Homoharringtonine/pharmacology[MESH] |Humans[MESH] |Immune Sera/immunology[MESH] |Immunization, Passive/methods[MESH] |Indoles[MESH] |Nelfinavir/pharmacology[MESH] |Neutralization Tests/*methods[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Pyrans/pharmacology[MESH] |Pyrroles/pharmacology[MESH] |SARS-CoV-2[MESH]Potential Antiviral Options against SARS-CoV-2 Infection (epmc).pdf DeepDyve Pubget Overpricing